Clinical trial · Observational
GastrOesophageal Tumor, Immune Microenvionnment (GOTIM)
A Prospective Clinicobiological Cohort Study Aiming to Decipher Tumor Immune Microenvironment Evolution Under Standard Chemotherapy in Localized and Resectable Gastric and Gastroesophageal Junctional Adenocarcinomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial is a prospective, monocentric, non-therapeutic, interventional cohort study aiming to decipher the immune TME through standard neoadjuvant CT in resectable G/GEJ adenocarcinomas. This study will also longitudinally monitor MRD during neoadjuvant and adjuvant therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| GastroEsophageal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Gastric and gastroesophageal junctional adenocarcinomas
- description
- Patient under standard chemotherapy in localized and resectable gastric and gastroesophageal junctional adenocarcinomas
Primary outcomes (1)
- measure
- Describe Gastric and Gastroesophageal immunological tumor microenvironment
- timeFrame
- At least 36 months following inclusion
- description
- Spatial, spectral cytometry, and transcriptomic analyses
Secondary outcomes (5)
- measure
- Understand the evolution of the immune tumor microenvironment and its spatial structuration through standard neoadjuvant chemotherapy.
- timeFrame
- At least 36 months following inclusion
- measure
- Characterize the evolution of the immune tumor environment profiles and organization between responder and non-responder patients under standard neoadjuvant treatment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Male or female patient \> 18 years of age on day of signing informed consent. * Histologically proven non-metastatic resectable gastric and gastroesophageal junction adenocarcinoma, Stage IB to III to be treated with standard neoadjuvant treatment. * Surgery of primary tumor to be done at Centre Léon Bérard. * Availability of archival FFPE tumor block from initial diagnosis with at least 20% of tumor cells. * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0, 1 or 2. * Patient should understand, sign, and date the written voluntary informed consent form at the screening visit prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol. * Patients must be covered by a medical insurance. Exclusion Criteria: * Any condition contraindicated with blood sampling procedures required by the protocol. * Known additional malignancy that is progressing or requires active treatment. Exceptions include adequately treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer * Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure. * Pregnant or breast-feeding woman.
References
Publications (0)
Data not yet available