Clinical trial · Observational
Cardiovascular Disorders and Risk Factors in Childhood Cranial and Craniospinal Tumors Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of research is to study to adverse cardiovascular disorder and risks factors in childhood cranial and craniospinal tumors survivors. In this research the investigators investigate cardiological instrumental diagnostic, such as electrocardiography, echocardiography with the determination of global longitudinal strain, cardiopulmonary exercise test, and diagnostic of endothelial function by Angioscan for the prediction of cardiovascular complications after cranial and craniospinal radiotherapy and chemotherapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer Survivors | — | UNRESOLVED | — |
| Tumors of the Central Nervous System | Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- childhood cancer survivors - the main group
- description
- childhood cancer survivals after complex management of cranial and craniospinal tumors formed the main group
- interventionNames
- Diagnostic Test: 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis
- label
- the control group
- description
- healthy people formed the control group
- interventionNames
- Diagnostic Test: 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis
Primary outcomes (3)
- measure
- Dyslipidemia
- timeFrame
- At baseline and through study completion of 1 year
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * radiation and chemotherapy for cranial and craniospinal tumors in childhood or adolescence * completion of the therapy at least one year before enrollment * signed informed consent * there were three separate types of informed consent - for adults, for minors and for their parents * minors were signing informed consent in the presence of their parents. Exclusion Criteria: * standard contraindications to exercise testing * anemia, pregnancy * psychiatric disease * alcohol or drug abuse * active malignancy * acute infection
References
Publications (0)
Data not yet available