Clinical trial · Observational
Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.
Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Tumors | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| no interventions between two groups | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- invasive PAs
- interventionNames
- Other: no interventions between two groups
- label
- non-invasive PAs
- interventionNames
- Other: no interventions between two groups
Primary outcomes (2)
- measure
- Residual tumor size
- timeFrame
- 1 week after surgery
- description
- Tumor size was evaluated by postoperative MRI
- measure
- tumor recurrence
- timeFrame
- three years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * 1\) histologically confirmed PAs, 2) Non-function pituitary adenomas Exclusion Criteria: * 1\) Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.
References
Publications (0)
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