Clinical trial · Interventional
LDCT-SC-FI Low-dose CT Screening for Lung Cancer
Low-dose CT Screening for Lung Cancer Combined to Different Smoking Cessation Methods in Finland
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomized phase II trial investigating different smoking cessation methods in study subjects undergoing lung cancer screening with low-dose CT (LDCT). The study also evaluates feasibility and outcomes of LDCT screening and potential biomarkers and AI-based evaluation on CT-scans. The study subjects fulfilling I/E-criteria are randomized in 1:1 fashion to yearly LDCT for two rounds with standard smoking cessation (control) or same LDCT approach combined to mobile application based smoking cessation (intervention).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer Screening | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Smoking cessation mobile application | Device | — | UNRESOLVED |
| Written material for smoking cessation | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Smoking cessation application
- interventionNames
- Device: Smoking cessation mobile application
- type
- ACTIVE_COMPARATOR
- label
- Written smoking cessation information
- interventionNames
- Behavioral: Written material for smoking cessation
Primary outcomes (1)
- measure
- Number of active smokers at 3 months
- timeFrame
- 3 months
- description
- The percentage of subjects who are actively smoking at 3 months after inclusion between the study arms
Secondary outcomes (8)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Able to provide written informed consent * Age between 50-74 * Smoked ≥ 15 cigarettes/day for ≥ 25 years or smoked ≥ 10 cigarettes/day for ≥ 30 years and are active smokers (smoking during the last two weeks) * Access to a smartphone (iPhone or Android) Exclusion Criteria: * A moderate or bad self-reported health; e.g. unable to climb two flights of stairs * Body weight ≥ 140 kilogram * Current or past melanoma, lung, renal or breast cancer * A chest CT examination less than one year before inclusion * Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial * Subject is unwilling or unable to comply with treatment and trial instructions * Any condition that study investigators consider an impediment to safe trial participation
References
Publications (1)
- DERIVEDIivanainen S, Kurtti A, Wichmann V, Andersen H, Jekunen A, Kaarteenaho R, Vasankari T, Koivunen JP. Smartphone application versus written material for smoking reduction and cessation in individuals undergoing low-dose computed tomography (LDCT) screening for lung cancer: a phase II open-label randomised controlled trial. Lancet Reg Health Eur. 2024 May 25;42:100946. doi: 10.1016/j.lanepe.2024.100946. eCollection 2024 Jul. PMID 39070744