Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

Inclusion Criteria:

* Age between 5 and 21 years, inclusive. Subjects younger than 5 years old may be eligible after discussion with the Sponsor Medical Monitor/designee (i.e. DSMB).
* Patient diagnosed with DIPG
* At least 4-week and not greater than 12 weeks from completion of radiation therapy
* Post-radiation imaging does not show evidence of necrosis/ hemorrhage or other features that contraindicate MRgFUS
* If brain surgery occurred, at least 14 days passed since last brain surgery and the patient is fully recovered and neurologically stable
* If on steroids, stable or decreasing dose for at least 7 days prior to study entry
* Stable or improving neurologic status for 7 days prior to study entry
* Able and willing to give consent and/or assent or have a legal guardian who is able and willing to do so
* Able to attend all study visits and with life expectancy of at least 6 months

Exclusion Criteria:

* Tumor not visible on any pre-therapy or post-radiation imaging
* Previous participation in other chemotherapy, molecularly targeted therapy, or immunotherapy treatment-related phase 1 or 2 trials
* Symptoms and signs of increased intracranial pressure
* Subject with metastatic disease
* Subject with ventricular peritoneal shunt
* Subject receiving bevacizumab (Avastin) therapy or increasing doses of steroids
* Anti-coagulant therapy, or medications known to increase risk of hemorrhage, (e.g., ASA, non-steroidal anti-inflammatory drugs \[NSAIDs\], statins) within washout period prior to treatment
* History of a bleeding disorder, coagulopathy or with a history of spontaneous tumor hemorrhage.
* Hypertension per age
* Cerebral or systemic vasculopathy, including intracranial thrombosis, vascular malformation, cerebral aneurysm, or vasculitis
* Immunosuppression (corticosteroids to prevent/treat brain edema are permitted).
* Patients with positive HIV status
* Active seizure disorder or epilepsy (seizures despite medical treatment) for a minimum of 4 weeks prior to first cycle/Exablate BBBD procedure captured by history
* Known sensitivity to gadolinium-based contrast agents
* Known sensitivity to DEFINITY® ultrasound contrast agent or known hypersensitivity to perflutren microsphere or its components, e.g., polyethylene glycol
* Contraindication to Doxorubicin
* Previous treatment with complete cumulative doses of Doxorubicin, daunorubicin, idarubicin, and/or other anthracyclines and anthracenediones
* Severely impaired renal function with estimated glomerular filtration rate \<2 standard deviations for age
* Patients that may require trastuzumab during the study
* Patients that may require inhibitors and inducers of CYP3A4, CYP2D6, and/or P-gp during the study