Clinical trial · Interventional
Comparison of Three Different Puncture Techniques in EBUS-TBNA
NCT05628454CI-TRIAL-00089083completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study was to compare the accuracy and sensitivity of slow-pull capillary technique, traditional suction aspiration and non negative pressure puncture in the diagnosis of mediastinal and/or hilar lymph node enlargement by ultrasound bronchoscopic lymph node biopsy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Sarcoidosis | — | UNRESOLVED | — |
| Tuberculosis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endobronchial ultrasound-guided transbronchial needle aspiration | Procedure | — | UNRESOLVED |
| Endobronchial ultrasound-guided transbronchial needle capillary sampling | Procedure | — | UNRESOLVED |
| Endobronchial ultrasound-guided transbronchial needle Slow-pull capillary sampling | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- EBUS-TBNSP
- description
- The slow-pull capillary technique was performed as follows: after identification and measurement of the target lymph node, a needle was used to puncture the lymph node with the stylet in place.At the same time, the stylet was slowly and continuously pulled to create weak negative pressure.
- interventionNames
- Procedure: Endobronchial ultrasound-guided transbronchial needle Slow-pull capillary sampling
- type
- EXPERIMENTAL
- label
- EBUS-TBNA
- description
- The operation steps are the same as above, but the negative pressure device of 10ml syringe is connected behind the puncture needle.
- interventionNames
- Procedure: Endobronchial ultrasound-guided transbronchial needle aspiration
- type
- EXPERIMENTAL
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18-80years * Chest computed tomography showing hilar or mediastinal lymph node enlargement * No contraindications for bronchoscopy * Signed informed consent provided by the patient * Disease needs to be diagnosed through the EBUS-TBNA Exclusion Criteria: * Severe coagulation dysfunction * Severe cardiopulmonary dysfunction * Acute asthma attack or massive haemoptysis * Poor general condition * Physical weakness without tolerance for anaesthesia or allergy to narcotic drug * Disease can be diagnosed by other less invasive methods (such as skin or peripheral superficial lymph node biopsy)
References
Publications (1)
- DERIVEDWu Y, Xu R, Duan X, Deng Y, Yu G, He X, Yao Z. Comparison of three different puncture techniques for endobronchial ultrasound transbronchial needle aspiration: a single-center, prospective, randomized controlled study. BMC Pulm Med. 2025 Sep 30;25(1):437. doi: 10.1186/s12890-025-03917-1. PMID 41029266