Clinical trial · Interventional
Effects for Oral Mucositis Care During Chemoradiotherapy in Cancer Patients: Evaluation of the Bee Products
Prevention and Improvement for Oral Mucositis Care During Chemoradiotherapy in Head and Neck Cancer Patients With Honey Production
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Oral mucositis is common among cancer patients receiving radiotherapy and chemotherapy. 80-90% of the patients are suffering from the mucositis pain; poor nutrition and even treatment discontinued. Some self-paid medications like glutamine has been used to prevent mucositis before and during radiotherapy/chemotherapy. Randomized controlled trials have shown that honey and propolis may be used for the management of mucositis. Honey demonstrates the most significant antibacterial effects; the green propolis has also been proved to comprise antibacterial, anti-inflammatory, and antioxidant effects. Bee products have been concerned as potential sources of natural antioxidants such as flavonoids, phenolic acids, and terpenoids. This study plan to conduct an RCT comparing the effectiveness of honey, honey and green propolis, and usual care in mucositis of cancer patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Mucositis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Honey product | Other | — | UNRESOLVED |
| propolis | Other | — | UNRESOLVED |
| Usual care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Honey
- description
- Each pack of 10 grams of honey after three meals a day.
- interventionNames
- Other: Honey product
- type
- EXPERIMENTAL
- label
- Honey and propolis
- description
- Each pack contains 0.7ml of propolis + 9.3g of honey after three meals a day.
- interventionNames
- Other: Honey product
- Other: propolis
- type
- PLACEBO_COMPARATOR
- label
- Usual care
- description
- General routine oral care.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: 1. diagnosed with a head and neck tumor. 2. receive chemotherapy or radiotherapy. 3. conscious clear and willing to participate in the research. 4. can communicate in Mandarin or Taiwanese. Exclusion Criteria: diabetes, arrhythmia, artificial heart rhythm device, allergic to bee products or alcohol.
References
Publications (0)
Data not yet available