Clinical trial · Interventional
Effect of Modified Endotracheal Intubation Protocol Combined With Early Oral Intake on Postoperative Recovery Quality in Thyroid and Parathyroid Surgery
Effect of Modified Endotracheal Intubation Protocol Combined With Early Oral Intake on Postoperative Recovery Quality in Thyroid and Parathyroid Surgery at a Tertiary Hospital in China: A 2x2 Factorial Randomized Controlled Trial Protocol
NCT05624463CI-TRIAL-00075559completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to assess the effect of modified endotracheal intubation procedure combined with early oral intake on postoperative recovery quality of patients, so as to further optimize the ERAS（enhanced recovery after surgery） program for thyroid or parathyroid surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Tumor | Thyroid Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional intubation protocol | Behavioral | — | UNRESOLVED |
| Delayed resumption of oral intake | Behavioral | — | UNRESOLVED |
| Early resumption of oral intake | Behavioral | — | UNRESOLVED |
| Modified intubation protocol | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Modified intubation protocol+early resumption of oral intake
- description
- Participants receive modified intubation protocol and early resumption of oral intake.
- interventionNames
- Behavioral: Modified intubation protocol
- Behavioral: Early resumption of oral intake
- type
- OTHER
- label
- Modified intubation protocol+delayed resumption of oral intake
- description
- Participants receive modified intubation protocol and delayed resumption of oral intake.
- interventionNames
- Behavioral: Modified intubation protocol
- Behavioral: Delayed resumption of oral intake
- type
- OTHER
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 * American Society of Anesthesiologists (ASA) physical status classification I-II * Body mass index 18.5-29.9kg/m2 * First operation on operation day Exclusion Criteria: * Patients or family members cannot understand the conditions and objectives of this study * Preoperative patients with acute pharyngitis, hoarseness, cough, dysphagia, and high risk of aspiration * The surgeons or anesthesiologists point out that the patient is not suitable for early postoperative drinking (such as considering the injury of recurrent laryngeal nerve or lymphatic vessels during the operation) * Patients who cannot be intubated under visual laryngoscope(such as difficult airway, loose incisors and so on) * Exclusion criteria of Quality of Recovery-15\* (\*Quality of Recovery-15 exclusion criteria: 1. Unable to understand words and language; 2. Difficult to cooperate due to mental disorders; 3. History of alcohol or drug abuse; 4. Any serious pre-existing medical condition that can limit the objective evaluation after surgery; 5. Any life-threatening complications; 6. Emergency surgery)
References
Publications (2)
- DERIVEDWu J, Zhang Y, Shen L. Modified versus conventional intubation and early versus delayed oral intake in thyroid surgery: a 2 x 2 factorial randomized controlled trial. Perioper Med (Lond). 2025 Oct 9;14(1):106. doi: 10.1186/s13741-025-00594-w. PMID 41068829
- DERIVEDWu J, Zhang Y, Shen L. Effect of modified endotracheal intubation protocol combined with early oral intake on postoperative recovery quality in thyroid and parathyroid surgery at a tertiary hospital in China: a 2x2 factorial randomised controlled trial protocol. BMJ Open. 2024 Jan 18;14(1):e075999. doi: 10.1136/bmjopen-2023-075999. PMID 38238052