Clinical trial · Observational
Pre-operative Therapy in Breast Cancer
The Effect of Pre-operative Therapy on Response and Survival in Breast Cancer
NCT05621564CI-TRIAL-00120408recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective and retrospective study to evaluate the effect of pre-operative therapy on response and survival, and compare the difference in response and survival by pre-operative regimen or by patient's clinicopathological characteristic in early or advanced breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pre-operative therapy | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- early breast cancer
- description
- no requirements for therapy
- interventionNames
- Drug: pre-operative therapy
- label
- advanced breast cancer
- description
- no requirements for therapy
- interventionNames
- Drug: pre-operative therapy
Primary outcomes (1)
- measure
- Pathologic Complete Response
- timeFrame
- at surgery
- description
- ypT0 ypN0, ypT0/is ypN0
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Female, Aged ≥18 years * Histologically confirmed primary breast cancer * Plan to receive pre-operative therapy * Adequate organ function Exclusion Criteria: * History of neurological or psychological disease, including epilepsy or dementia * Not suitable to participate in this study judged by investigators
References
Publications (1)
- DERIVEDChen X, Zhao Y, Wang Y, Ye Y, Xu S, Zhou L, Lin Y, Lu J, Yin W. Serum lipid ratios as novel prognostic biomarkers for patients with locally advanced breast cancer treated with neoadjuvant therapy. Postgrad Med. 2024 Jun;136(5):541-550. doi: 10.1080/00325481.2024.2370235. Epub 2024 Jun 24. PMID 38912905