Clinical trial · Interventional
Vinegar-induced Collection of Duodenal Pancreatic Juice Via Endoscopic Ultrasound
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to learn about the feasibility of collecting pancreatic juice through duodenal aspiration by ultrasound endoscopy (EUS) for molecular marker testing after intraduodenal infusion of vinegar in patients with suspected pancreatic cancer and who are scheduled to have endoscopic ultrasound with fine needle aspiration (EUS-FNA). The main questions it aims to answer are: * Is vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound feasible? * What is the best operating condition (amount of vinegar, collection time, etc.) of vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound? Participants will have EUS as scheduled, during which different amount of vinegar will be infused into duodenum and then pancreatic juice be collected for different time via suction by EUS. Researchers will compare the amount of collected pancreatic juice and molecular marker level in different groups to determine the best operating condition for vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Saline (NaCl 0,9 %) (placebo) | Drug | — | UNRESOLVED |
| Vinegar 20ml | Drug | — | UNRESOLVED |
| Vinegar 40ml | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Normal Saline Group
- description
- Inject 20ml normal saline solution into duodenum and collect the pancreatic juice for 15 minutes via EUS, changing the collection bottle every 5 minutes.
- interventionNames
- Drug: Saline (NaCl 0,9 %) (placebo)
- type
- EXPERIMENTAL
- label
- Vinegar 20ml Group
- description
- Inject 20ml vinegar (5% acetic acid solution) into duodenum and collect the pancreatic juice for 15 minutes via EUS, changing the collection bottle every 5 minutes.
- interventionNames
- Drug: Vinegar 20ml
- type
- ACTIVE_COMPARATOR
- label
- Vinegar 40ml Group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age: 18 years old or older * Diagnosis: CT, MRI, transabdominal ultrasound or other imaging examinations showed a pancreatic mass, and 3 endoscopists agreed on the diagnosis of suspected pancreatic cancer * EUS-FNA is required to perform further treatment strategy * The patient can understand the study protocol, is willing to participate in the study and can provide written informed consent Exclusion Criteria: * The patient's clinical and imaging features do not support the diagnosis of suspected pancreatic cancer, judged by 3 endoscopists * The patient refuses to have EUS-FNA * The patient is unsuitable for EUS-FNA because of his/her general condition, or contraindicated for anesthesia * The patient's imaging suggests severe pancreatic duct obstruction * The patient cannot understand the conditions and objectives of this study, or refuse to participate in the study
References
Publications (0)
Data not yet available