Clinical trial · Observational
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Detection of Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors Exposed to Cisplatin-based Chemotherapy and Bone Marrow Transplant
NCT05611307CI-TRIAL-00119391recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ASCVD | — | UNRESOLVED | — |
| Bone Marrow Transplant Complications | — | UNRESOLVED | — |
| Cisplatin Adverse Reaction | — | UNRESOLVED | — |
| Coronary Artery Disease | — | UNRESOLVED | — |
| Hypogonadism, Male | — | UNRESOLVED | — |
| Lipid Disorder | — | UNRESOLVED | — |
| Survivorship | — | UNRESOLVED | — |
| Testicular Cancer | Malignant Testicular Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Coronary artery assessment | Diagnostic Test | — | UNRESOLVED |
| Hormone levels for hypogonadism | Diagnostic Test | — | UNRESOLVED |
| Lipid profile | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Surgical/Surveillance
- description
- TCS cured with surgical resection and surveillance (surgical/surveillance, Arm 1)
- interventionNames
- Diagnostic Test: Lipid profile
- Diagnostic Test: Coronary artery assessment
- Diagnostic Test: Hormone levels for hypogonadism
- label
- Cisplatin-based chemotherapy (CBCT)
- description
- TCS treat with one or more lines of cisplatin-based chemotherapy
- interventionNames
- Diagnostic Test: Lipid profile
- Diagnostic Test: Coronary artery assessment
- Diagnostic Test: Hormone levels for hypogonadism
- label
- Cisplatin-based chemotherapy and Bone Marrow Transplant (CBCT/BMT)
- description
- TCS treat with one or more lines of cisplatin-based chemotherapy, and who have undergone bone marrow transplant
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria * Patients \>18 years of age * Patients will be recruited only if cancer-free at clinical evaluation time. * For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2) * For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT \& BMT group, Arm 3). * For the comparison cohort, biopsy-proven TC patients who had surgery for or surveillance of their testicular cancer and never received CBCTCBCT or BMT (surgical/surveillance, Arm 1) Exclusion Criteria * Prior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD) * Significant renal disease (GFR\<40) * Allergy to iodinated contrast * Antecedent chemotherapy for another primary cancer.
References
Publications (0)
Data not yet available
No reference posted for this study.