Clinical trial · Observational
Pancreatic and Periampullary Tumors in Greenland Inuit
The Outcome After Operation for Pancreatic and Periampullary Tumors in Greeland Inuit.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Especially since the Second World War the indigenous population in the Arctic, the Inuit have gone through a Westernization, which has improved the health conditions but also changed the disease panorama with an increasing incidence of cancer. This is exemplified by a decrease in physical activity, due to the depletion of the Greenlandic hunting traditions, tobacco smoking and unhealthy diet. At the beginning of the westernization, malignant diseases were highly uncommon, but they started to increase due to the increasing life expectancy and changes in lifestyle. The incidence of pancreatic and periampullary cancer has been reported to be the same among Inuit in Canada, Denmark, and the United States but with a higher incidence than among the Caucasian population in the three countries. The aim with this study was to investigate the results of pancreatic surgery for pancreatic and periampullary tumors in Inuit patients in Greenland at to compare the outcome of surgery and the overall survival with a cohort of Danish patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Neoplasms | Pancreatic Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Periampullary Neoplasms | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| outcome following surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Inuit
- description
- Inuit living in Greenland
- interventionNames
- Other: outcome following surgery
- label
- Danish
- description
- Danish patients living in Denmark
- interventionNames
- Other: outcome following surgery
Primary outcomes (3)
- measure
- waiting time from diagnosis to surgery
- timeFrame
- from 31. January 1999 to 31. January 2021
- description
- time from diagnosis to surgery for each patient
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 41 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * Greenland Inuit patients * operated for pancreatic and periampullary cancer * time of operation 31. January 1999 to 31. January 2021 * sex: all * minimum age: 41 years * maximum years: 79 years Exclusion Criteria * patients beyond the age limit * patients operated beyond the time limit Danish patients * operated for pancreatic and periampullary cancer * time of operation 31. January 1999 to 31. January 2021 * sex: all * minimum age: 41 years * maximum years: 79 years Exclusion Criteria: patients beyond the age limit. * patients beyond the age limit. * time of operation 31. January 1999 to 31. January 2021
References
Publications (27)
- BACKGROUNDGBD 2017 Pancreatic Cancer Collaborators. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):934-947. doi: 10.1016/S2468-1253(19)30347-4. Epub 2019 Oct 21. PMID 31648972
- BACKGROUNDRawla P, Sunkara T, Gaduputi V. Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J Oncol. 2019 Feb;10(1):10-27. doi: 10.14740/wjon1166. Epub 2019 Feb 26. PMID 30834048
- BACKGROUNDBjerregaard P, Curtis T, Borch-Johnsen K, Mulvad G, Becker U, Andersen S, Backer V. Inuit health in Greenland: a population survey of life style and disease in Greenland and among Inuit living in Denmark. Int J Circumpolar Health. 2003;62 Suppl 1:3-79. doi: 10.3402/ijch.v62i0.18212. PMID 14527126
- BACKGROUNDFriborg JT, Melbye M. Cancer patterns in Inuit populations. Lancet Oncol. 2008 Sep;9(9):892-900. doi: 10.1016/S1470-2045(08)70231-6. PMID 18760245
- BACKGROUNDCircumpolar Inuit Cancer Review Working Group; Kelly J, Lanier A, Santos M, Healey S, Louchini R, Friborg J, Young K, Ng C. Cancer among the circumpolar Inuit, 1989-2003. I. Background and methods. Int J Circumpolar Health. 2008 Dec;67(5):396-407. doi: 10.3402/ijch.v67i5.18348. PMID 19186761
- BACKGROUNDYousaf U, Engholm G, Storm H, Christensen N, Zetlitz E, Trykker H, Sejersen F, Bjerregaard P, Thygesen LC. Cancer Incidence and Mortality in Greenland 1983-2014 - Including Comparison With the Other Nordic Countries. EClinicalMedicine. 2018 Aug 29;2-3:37-49. doi: 10.1016/j.eclinm.2018.08.003. eCollection 2018 Aug-Sep. PMID 31193566
- BACKGROUNDSchmidt M, Pedersen L, Sorensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014 Aug;29(8):541-9. doi: 10.1007/s10654-014-9930-3. Epub 2014 Jun 26.