Clinical trial · Interventional
Anatomical Radiofrequency Ablation for Small Hepatocellular Carcinoma
Anatomical Radiofrequency Ablation for Peripherally Located Small Hepatocellular Carcinoma Using Combined Energy Delivery Mode and Triple Cooled-Wet Electrodes
NCT05580224CI-TRIAL-00061451unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to investigate therapeutic outcomes of anatomical radiofrequency ablation for peripherally located small hepatocellular carcinoma using combined energy delivery mode and triple cooled-wet electrodes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiofrequency ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients with hepatocellular carcinoma (equal or less than 3 cm)
- description
- Under the guidance of multimodality-ultrasound (US) fusion image, one of the three electrodes was placed across the portal vein branch near the tumor, and the other two electrodes were placed around the tumor through the previously planned approach path. After placement of electrodes, the temperature is maintained at 90-100 degrees Celsius for about 6-30 minutes depending on the size of the tumor, using the combined energy transfer mode that sequentially adds the bipolar mode and/or the monopolar mode.
- interventionNames
- Procedure: Radiofrequency ablation
Primary outcomes (2)
- measure
- Technical success
- timeFrame
- Immediately after radiofrequency ablation
- description
- Technical success addresses whether the index tumor was treated according to a predefined protocol and entirely covered by the ablation zone.
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Child-Pugh class A or B7. * Presence of chronic hepatitis B or liver cirrhosis. * Patients with hepatocellular carcinomas diagnosed by histopathology or noninvasive imaging-based diagnosis according to the Korean Liver Cancer Association-National Cancer Center Korea guidelines. * Patients with viable hepatocellular carcinoma after locoregional treatment diagnosed by the Liver Imaging Reporting and Data System. * Tumor location is less than 5 cm from liver capsule. Exclusion Criteria: * The number of tumor is three or more. * Tumor size is over 3 cm. * Tumor location is over 5 cm from liver capsule. * Child-Pugh class B8-9 or C. * Presence of macrovascular invasion and/or distant metastasis. * Platelet count \< 50,000 mm3, or international normalized ratio \> 1.5 (prothrombin time \>1.5 × normal).
References
Publications (0)
Data not yet available
No reference posted for this study.