SBRT Versus Conventional Fractionated Radiotherapy for Vertebral Metastases

Vertebral metastases are events that affect the quality of life of tumor patients, and are often accompanied by severe pain at the site of metastasis and even by the risk of compression fracture. For vertebral metastases who are not yet at risk of vertebral instability fracture, a moderate dose (30Gy/10F) external radiation therapy is the most widely used treatment technique. Previous studies have shown that 60-80% of patients could achieve pain relief with moderate doses of radiation therapy, with median pain control duration of approximately 4 months. Stereotactic Radiation Therapy (SBRT) is currently the most advanced radiation therapy technique. This project proposes to treat vertebral metastases from non-small cell lung cancer using SBRT technology on the True Beam radiotherapy system to compare its efficacy with conventional external irradiation technology in terms of pain relief as well as local control.

Sex

All

Minimum age

18 Years

Maximum age

80 Years

Inclusion Criteria:

* Pathologically confirmed stage IV non-small cell lung cancer.
* General condition score ≤ 2.
* With vertebral metastases combined with painful symptoms.
* Absence of neurological symptoms due to vertebral metastases, such as dyskinesia, defecation or urination abnormalities.
* No previous radiation treatment of any kind to the vertebral body.
* The metastatic vertebra has not been treated surgically
* Vertebral stability score (SINS) ≤ 12
* Patient life expectancy of more than 6 months.

Exclusion Criteria:

* Small cell cell lung cancer or large cell carcinoma
* General condition score \>2, intolerant of radiotherapy.
* Comorbid neurological symptoms such as dyskinesia, abnormal bowel movements or urination
* Metastatic vertebrae that have received radiotherapy or surgical intervention
* Vertebral stability score (SINS) \>12
* Patient life expectancy of less than 6 months