Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples

Breast cancer is the most common cancer and cause of cancer- related deaths among women, accounting for 1.67 million (25.2%) new cases and 521,907 (14.7%) deaths worldwide. The prevalence and survival rates of breast cancer differ per country. In Indonesia, majority of patients (70.9%) go to the clinic with advanced stages of breast cancer. Five-year survival rate is 51.07%. One of the most important determinants of survival is education level and stage of breast cancer. Current screening methods include mammography and radiology assessments, both of which have disadvantages specifically in Asian population. Mammography is less useful in Asian population because the population has denser breast, resulting to failure to diagnose cases of breast cancer in this population in 37-70% of cases. Moreover, screening methods provide binary answers, and therefore does not inform risk profile of the patients. The investigators aim to implement PRS into the breast cancer screening process while observing the differences of genetic and non-genetic risk factor in patients with breast cancer and patients without any medical/family history of breast cancer in Indonesian population.

Sex

Female

Minimum age

35 Years

Maximum age

75 Years

Inclusion Criteria:

* For case group

  1. Had been diagnosed with primary breast cancer or tested positive for high penetrance genes (e.g. BRCA 1/2)
  2. Menarche age \>12 years old
  3. Premenopausal
* For control group

  1. Premenopausal
  2. Menarche age \>12 years old
  3. Asymptomatic
  4. Consented for the study and follow up

Exclusion Criteria:

* For case group:

First degree family history of breast or ovarian cancer

* For control group:

  1. Family history of breast or ovarian cancer
  2. First-degree relationship with the cases

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