Clinical trial · Observational
A Real-world Comparison of FNB and FNA in IHC-required Lesions.
A Real-world Comparison of FNB and FNA in IHC-required Lesions: A Prospective, Multicenter Study.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Endoscopic ultrasound (EUS)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis. The investigators conducted a large, multicenter study to compare the accuracy of diagnosis via specimens collected with fine-needle biopsy (FNB) versus fine-needle aspiration (FNA) for patients with lesions requiring immunohistochemistry (IHC) pathological diagnosis.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Autoimmune Pancreatitis | — | UNRESOLVED | — |
| Gastrointestinal Stromal Tumors | Gastrointestinal Stromal Tumor | ONTOLOGY_EXACT | 0.98 |
| Neuroendocrine Tumors | Neuroendocrine Tumor | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| FNA group | Device | — | UNRESOLVED |
| FNB group | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- FNB group
- description
- FNB needles adpted to acquire lesion tissues according patients' advice and patients' willings.
- interventionNames
- Device: FNB group
- label
- FNA group
- description
- FNA needles adpted to acquire lesion tissues according patients' advice and patients' willings.
- interventionNames
- Device: FNA group
Primary outcomes (4)
- measure
- Diagnostic yields of EUS-FNA with EUS-FNB for solid masses
- timeFrame
- From admission until the date of pathological diagnosis obtained or follow-up up to 24 months
- description
- Overall dignostic yields of all solid lesions
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age \>18 years; * presence of a solid mass lesion was confirmed by at least 1 imaging modality and it was located within pancreas, abdomen, mediastinum, or pelvic cavity; * mass size \>1 cm; * final diagnoses were obtained after surgery, imaging analysis, or resolution of the lesion, including AIP, NET, mesenchymal tumors, and lymphoma. Exclusion Criteria: * coagulopathy (international normalized ratio, 1.5); * thrombocytopenia (platelet count \<50,000/mm3); * acute pancreatitis within the previous 2 weeks; * inability to safely perform EUS-TA (eg, cardiorespiratory dysfunction, mental diseases, or drug addiction); * refusal or inability to provide an informed consent.
References
Publications (0)
Data not yet available