Clinical trial · Interventional
Role of Laparoscopy in Assessing Resectability of Ovarian Cancer
Role of Laparoscopy in Assessing Tumor Resectability in Ovarian Cancer Cases
NCT05564234CI-TRIAL-00061212completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim of Work is Prevention of unnecessary laparotomies and failed attempts to perform optimal cytoreduction in women with advanced ovarian cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laparoscopy then neoadjuvant chemotherapy followed by interval cytoreductive surgery | Procedure | — | UNRESOLVED |
| laparoscopy then primary cytoreductive surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Neoadjuvant chemotherapy
- description
- cases with predictive index value score 8 or greater in which primary cytoreductive surgery was not feasible were were referred for neoadjuvant chemotherapy then interval cytoreductive surgery was done
- interventionNames
- Procedure: laparoscopy then neoadjuvant chemotherapy followed by interval cytoreductive surgery
- type
- ACTIVE_COMPARATOR
- label
- primary cytoreductive surgery
- description
- cases with predictive index value score less than 8 were offered primary cytoreductive surgery.
- interventionNames
- Procedure: laparoscopy then primary cytoreductive surgery
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with suspicious ovarian cancer by clinical and radiological assessment are included in this study. Exclusion Criteria: * Patients with poor Eastern Cooperative Oncology Group grade more than 2. * Medical comorbidities at the time of diagnosis precluding primary surgery, newly diagnosed deep venous thrombosis or pulmonary embolus within 6 weeks of presentation. * Immobile pelvic tumor reaching to xiphisternum leading to conclusions that complete cytoreductive surgery is not feasible * Intrahepatic metastatic disease of more than one centimetre * Para-aortic lymphadenopathy larger than one centimetre above the level of the renal veins * Any contraindication for laparoscopy as cardiopulmonary compromise, intracranial diseases or large ventral hernia.
References
Publications (3)
- BACKGROUNDFagotti A, Ferrandina G, Fanfani F, Ercoli A, Lorusso D, Rossi M, Scambia G. A laparoscopy-based score to predict surgical outcome in patients with advanced ovarian carcinoma: a pilot study. Ann Surg Oncol. 2006 Aug;13(8):1156-61. doi: 10.1245/ASO.2006.08.021. Epub 2006 Jun 21. PMID 16791447
- BACKGROUNDFagotti A, Ferrandina G, Fanfani F, Garganese G, Vizzielli G, Carone V, Salerno MG, Scambia G. Prospective validation of a laparoscopic predictive model for optimal cytoreduction in advanced ovarian carcinoma. Am J Obstet Gynecol. 2008 Dec;199(6):642.e1-6. doi: 10.1016/j.ajog.2008.06.052. Epub 2008 Sep 17. PMID 18801470
- BACKGROUNDFleming ND, Nick AM, Coleman RL, Westin SN, Ramirez PT, Soliman PT, Fellman B, Meyer LA, Schmeler KM, Lu KH, Sood AK. Laparoscopic Surgical Algorithm to Triage the Timing of Tumor Reductive Surgery in Advanced Ovarian Cancer. Obstet Gynecol. 2018 Sep;132(3):545-554. doi: 10.1097/AOG.0000000000002796. PMID 30095787