Clinical trial · Interventional
Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors
The Influence of Excess Adiposity on Cardiorespiratory, Insulin-like Growth Factor, and Metabolic Responses to a Standardized Aerobic Exercise Program in Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Overweight and Obesity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aerobic Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Aerobic exercise
- description
- 15-week standardized aerobic exercise intervention
- interventionNames
- Behavioral: Aerobic Exercise
Primary outcomes (3)
- measure
- Recruitment
- timeFrame
- up to 12 months
- description
- Number of participants joining the study per month
- measure
- Study Adherence
- timeFrame
- up to 12 months
- description
- Percentage of participants completing pre- and post-intervention assessments
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * Primary cancer diagnosis of breast, prostate, or colorectal cancer * Completion of all cancer-related treatment \> than 6 months prior and \< 5 years prior to enrollment * Ability and willingness to participate in a supervised exercise program * All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment Exclusion Criteria: * Presence of a secondary active cancer diagnosis or metastatic disease * Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months * Greater than 100 min of self-reported regular exercise per week * BMI \< 18.5 (underweight) * Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded. * Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including: * Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries * Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia * Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease * Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
References
Publications (0)
Data not yet available