Clinical trial · Interventional
STAY-STRONG Study of Exercise Training During Chemotherapy
The Effect of Resistance Training in Patients With Malignant Lymphoma Undergoing Chemotherapy Treatment - the STAY STRONG TRIAL - a Randomized Controlled Trial.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluates the effectiveness of a supervised progressive resistance training program in patients malignant lymphomas with the primary outcome being lean body mass. The study is designed as a a single center, two-armed, parallel-group, investigator-initiated clinical randomized controlled superiority trail evaluating the effectiveness of a 4-month supervised progressive resistance training intervention compared to usual care.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Body Composition | — | UNRESOLVED | — |
| Exercise | — | UNRESOLVED | — |
| Lymphoma, B-Cell | B-Cell Malignant Neoplasm | CURATED_BROADER | 0.80 |
| Lymphoma, Hodgkin | Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Muscle, Skeletal | — | UNRESOLVED | — |
| Patient Reported Outcome Measures | — | UNRESOLVED | — |
| Physical Functional Performance | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Resistance Exercise Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- The usual care group
- description
- The usual care group receives standard care in accordance to current clinical practice at Rigshospitalet
- type
- EXPERIMENTAL
- label
- Resistance Exercise Training
- description
- Patients included in the intervention group will receive usual care plus the exercise training intervention.
- interventionNames
- Behavioral: Resistance Exercise Training
Primary outcomes (1)
- measure
- Lean Body Mass
- timeFrame
- Baseline, 4-month follow-up, 8-month follow-up, 1-year follow-up
- description
- Change in lean body mass. Assessed by whole-body dual-energy x-ray absorptiometry (DXA) scan.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participants must: * Be newly diagnosed with diffuse large B-cell lymphoma and Hodgkin Lymphoma * Be expected to receive treatment with an anthracycline-containing combination chemotherapy at the Department of Hematology, Rigshospitalet * Be ≥ 18 years of age at the time of signing the informed consent form. * Be residing in Denmark * Have an Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2 * Be able to speak and read Danish, and to provide a signed informed consent form. Exclusion Criteria: * Patients with: * Clinically significant cardiovascular disease, including, but not limited to: Heart failure NYHA (New York Heart Association) class III-IV, uncontrolled hypertension, and symptomatic cardiac arrhythmias. * Psychiatric, neurological, or geographical conditions that could influence protocol adherence. * Disorders that cause an inability to perform exercise training for one hour. * Any other known malignancy requiring active treatment.
References
Publications (1)
- DERIVEDErnst M, Wagner C, Oeser A, Messer S, Wender A, Cryns N, Brockelmann PJ, Holtkamp U, Baumann FT, Wiskemann J, Monsef I, Scherer RW, Mishra SI, Skoetz N. Resistance training for fatigue in people with cancer. Cochrane Database Syst Rev. 2024 Nov 28;11(11):CD015518. doi: 10.1002/14651858.CD015518. PMID 39606939