Clinical trial · Interventional
The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
The Effect of Ultrasound-guided Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions and Analgesia After Breast Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. Serratus anterior plane block is used to block lateral cutaneous branches of intercostal nerves between T2 and T6, in addition, it is also known to block thoracodorsal nerve and long thoracic nerve. Both of the blocks are usually performed for postoperative analgesia following breast surgery. The primary hypothesis of the study is that FEV1 value of the patients who will receive modified radical mastectomy (MRM) and rhomboid intercostal plane (RIP) block combined with serratus anterior plane (SAP) will be higher than FEV1 value of the patients in the no-block group. The secondary hypothesis is that RIP+SAP blocks will provide reduction in the pain scores and opioid consumption in the postoperative first 24 hours.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Postoperative Pain | — | UNRESOLVED | — |
| Respiratory Function Impaired | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RIB+SAP blocks | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Block Group
- description
- After endotracheal intubation, patients will be positioned in lateral decubitus position. A linear ultrasound probe will be placed at the edge of scapula at the level of T5-T6. Under sterile conditions, the landmark points (rhomboid major muscle, 5th and 6th ribs, and intercostal muscles) will be observed and a block needle will be directed to the interfacial plane between rhomboid major muscle and intercostal muscle. RIB will be performed by injecting 20 ml of bupivacaine 0.25%. In the same position, the probe will be placed at the midaxillary line at the level of T3, and the landmark points (latissimus dorsi muscle and serratus muscle and intercostal muscles) will be observed. Under sterile conditions, a SAP block will be performed by injecting 20 ml of Bupivacaine 0.25% into the plane between serratus muscle and intercostal muscle.
- interventionNames
- Procedure: RIB+SAP blocks
- type
- NO_INTERVENTION
- label
- Control Group
- description
- No block procedures will be performed in this group.
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ASA I-II patients * Female * Ages between 18-65 * Patients who will receive breast cancer surgery under general anesthesia Exclusion Criteria: * Known respiratory diseases * Rhinitis and atopic dermatitis story * New York Heart Association Class equal to higher than class 2 * Respiratory diseases story in the last two weeks * Alchol or substance or chronic opioid consumption story * Any pain killers intake in the last 24 hours prior to surgery * Active smokers or ex-smokers * Body mass index over 35 kg/m2 * İnfection at the injection sites * Known allergy to local anesthetics * Known psychiatric diseases * Operations longer than 3 hours
References
Publications (1)
- DERIVEDAkgun G, Altiparmak B, Pinarbasi A, Toker MK, Pektas S, Ugur B. Impact of ultrasound-guided rhomboid intercostal and serratus anterior plane blocks on respiratory function after modified radical mastectomy: a randomized controlled trial. Korean J Anesthesiol. 2026 Feb;79(1):104-113. doi: 10.4097/kja.25150. Epub 2025 Jun 26. PMID 40567200