Clinical trial · Interventional
Coeliac Plexus Neurolysis Versus Splanchnic Nerve Neurolysis
Comparing the Effects of Coeliac Plexus Neurolysis Versus Splanchnic Nerve Neurolysis for Non-pancreatic Upper Intra-abdominal Cancer Pain: a Prospective Randomized Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pain is prevalent among patients with gastrointestinal cancers. Standard procedures such as coeliac plexus neurolysis (CPN) is effective in reducing pain, opioid requirement and related side effects for pancreatic cancer cases. Meanwhile, splanchnic nerve neurolysis (SNN) as an alternative to CPN is more effective for cancer pain relief. Although previous studies investigating the role of CPN/SNN mainly focus on pancreatic cancer cases, their efficacy on non-pancreatic abdominal cancer pain may not be accurately determined.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Coeliac plexus neurolysis | Other | — | UNRESOLVED |
| Splanchnic nerve neurolysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Coeliac plexus neurolysis (CPN)
- description
- Coeliac plexus neurolysis (CPN) will be performed bilaterally. Neurolytic solution will be injected around the coeliac plexus (a network of nerves located in the abdomen).
- interventionNames
- Other: Coeliac plexus neurolysis
- type
- EXPERIMENTAL
- label
- Splanchnic nerve neurolysis (SNN)
- description
- Splanchnic nerve neurolysis (SNN) will be performed bilaterally. Neurolytic solution will be injected around the splanchnic nerves (a nerve located at thoracic trunk).
- interventionNames
- Other: Splanchnic nerve neurolysis
Primary outcomes (1)
- measure
- pain score
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age\>=18 * Diagnosis of unresectable intra-abdominal cancer * Visceral pain attributable to the cancer with NRS \>= 4 * Able to understand instructions, give consent, complete questionnaires Exclusion Criteria: * Primary pancreatic cancer or metastatic disease involving pancreas * Gross celiac axis distortion identified on imaging * Acute abdomen condition eg. Intraabdominal sepsis, tumor rupture * Other non-cancer causes attributable to the pain * Gross ascites * Previous coeliac plexus or splanchnic nerve neurolysis * Contraindications to neurolytic procedures eg. Bleeding tendency; local or systemic infections; allergic to local anesthetics, contrast or alcohol; intestinal obstruction; anatomical distortion along needle trajectory * Patients believed to be inappropriate for study by investigators
References
Publications (0)
Data not yet available