Clinical trial · Interventional
Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy
Effect of Donepezil on Prevention of Postoperative Urinary Retention in Patients Undergoing Extensive Total Hysterectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients were randomly divided into experimental group and control group. The control group received routine postoperative treatment, while the experimental group took donepezil 5mg orally before going to bed every night from the first day after surgery. The catheter was removed and residual urine was measured in both groups 14 days after surgery, the catheter was successfully removed when the residual urine was less than 100ml. After 14 days, the patient was returned to the hospital for residual urine test, and the residual urine was repeated until the residual urine volume was less than or equal to 100ml. The incidence of postoperative urinary retention and adverse drug reactions were compared between the two groups.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Urinary Retention After Procedure | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Donepezil | Drug | — | UNRESOLVED |
| Usual care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Donepezil
- description
- Patients were randomly divided into experimental group and control group. The experimental group received routine postoperative treatment and took donepezil 5mg orally before going to bed every night from the first day after surgery.
- interventionNames
- Drug: Donepezil
- type
- OTHER
- label
- Usual care
- description
- Usual care
- interventionNames
- Other: Usual care
Primary outcomes (1)
- measure
- The incidence of urinary retention (residual urine volume < 100ml)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18-80 years 2. Patients who meet the diagnostic criteria of cervical cancer in the Guidelines for the Diagnosis and Treatment of Cervical Cancer (the Fourth Edition) and have been diagnosed by cervical biopsy or colposcopy 3. Patients with surgical indications undergoing extensive abdominal total hysterectomy 4. The person who signed the informed consent. Exclusion Criteria: 1. Allergic reaction to donepezil hydrochloride, piperidine derivatives or excipients in preparations 2. Patients with "sick sinus syndrome" or other supraventricular heart conduction diseases 3. Accompanied by serious liver, kidney and other organ dysfunction, serious infectious diseases 4. Patients with a history of mental illness and communication disorders 5. At the time of inclusion, patients with urinary tract infection had a history of urinary tract diseases (stones, congenital malformations, etc.) 6. Patients with intraoperative injury of urinary system, or postoperative ureteral fistula and vesicovaginal fistula.
References
Publications (0)
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