Clinical trial · Observational
Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Neoplasms | Rectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Pathological complete response
- description
- Patients with a complete response to the neoadjuvant therapy on the definitive anatomopathology study.
- label
- Non pathological complete response
- description
- Patients without complete response to the neoadjuvant therapy on the definitive anatomopathology study.
Primary outcomes (1)
- measure
- Complete response MRI criterion
- timeFrame
- Day 0: immediately after the procedure
- description
- We selected several objective MRI criterion among literature and compared them between the two groups.
Secondary outcomes (1)
- measure
- MRI accuracy
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Rectal adenocarcinoma * Locally advanced * Neoadjuvant therapy * MRI restaging * Rectal surgery * Definitive anatomopathology study
References
Publications (0)
Data not yet available