Clinical trial · Observational
Cardio-Oncology Rehabilitation Exercise
A Single Arm Intervention Study to Assess the Role of Structured Cardio-Oncology Rehabilitation Exercise to Improve Cardiovascular Health in Early Stage Breast Cancer Survivors (CORE Study)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study. Participants will take part in an established 16-week multimodal cardiac rehabilitation program (HEALTh program) at Toronto Rehabilitation Institute and outcome measures will be assessed before and after program participation to determine the effectiveness of the program in improving cardio metabolic health. Change in VO₂peak will be assessed using Cardiopulmonary Exercise Test (CPET). Traditional cardiac risk factors, lifestyle behaviours, exercise adherence, health-related quality of life, and fatigue will also be assessed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Cardiopulmonary Fitness
- timeFrame
- post-intervention (16 weeks)
- description
- VO2peak assessed using cardiopulmonary exercise test
Secondary outcomes (11)
- measure
- Visceral adipose tissue
- timeFrame
- post-intervention (16 weeks)
- description
- Measured only in a subset (n=30) of participants via 1.5T MRI.
- measure
- Left ventricular ejection fraction
- timeFrame
- post-intervention (16 weeks)
- description
- Measured only in a subset (n=30) of participants via 1.5T MRI.
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * History of early-stage breast cancer (I-III) * Currently receiving or have completed adjuvant therapy (i.e. chemotherapy, surgery, radiation, targeted therapies) * Able to communicate in English Exclusion Criteria: * Pregnancy * Metastatic disease (Stage IV) * Unable or unwilling to complete cardiopulmonary exercise test
References
Publications (0)
Data not yet available