Clinical trial · Interventional
Short-term Psychodynamic Psychotherapy in Serious Physical Illness
ORPHYS - Short-term Psychodynamic Psychotherapy in Serious Physical Illness
NCT05520281CI-TRIAL-00098921ORPHYScompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Life-threatening physical illness may powerfully re-activate existential conflict. There is little evidence to date on the effectiveness of relationship-focused therapies in this patient group.The aim of this study is to pilot a psychodynamic treatment for patients with advanced cancer and high psychological distress.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma | Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Malignant Neoplasm | Malignant Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Palliative Care | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Short-term psychodynamic psychotherapy for patients with serious physical illness (ORPHYS) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients
- description
- Adult patients across all phases of advanced disease (UICC stage IV solid tumor) from diagnosis to terminal stages
- interventionNames
- Behavioral: Short-term psychodynamic psychotherapy for patients with serious physical illness (ORPHYS)
Primary outcomes (5)
- measure
- Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
- timeFrame
- up to 12-months follow-up
- description
- Will be assessed via Inventory for the Balanced Assessment of Negative Effects of Psychotherapy (INEP, Ladwig, Rief \& Nestoriuc, 2014).
- measure
- Acceptance
- timeFrame
- through study completion, an average of 6 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years and older * UICC stage IV solid tumor * Informed consent * Current physical condition that allows for at least 12 therapy sessions * Indication: Presence of a mental disorder with existential stress and limitations in coping capacity Exclusion Criteria: * Acute suicidality * Psychotic disorder (ICD-10: F2 diagnosis) * Substance dependence or abuse (ICD-10: F1 diagnosis) * Structural deficits that interfere with attending to regular appointments * Other psychotherapeutic treatment * Severe cognitive impairment * Severe physical impairment * Insufficient German to give informed consent and complete self-report questionnaires
References
Publications (0)
Data not yet available
No reference posted for this study.