Clinical trial · Observational
Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas
Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) is a non-interventional, multicentric, international, clinical and epidemiologic patient registry. The COSS-Registry collects key data on osteosarcomas or biologically related bone sarcomas. With that data collection we want to gain new scientific insights and results about this tumor disease, prognosis, surveillance and long-term effects. Besides the data collection we would also like to foster the collection of biomaterial (tumor specimen and blood samples) for scientific research. The stored material will be used to perform cell and molecular biological analyses to identify the causes of osteosarcoma, the prognosis and possible new treatment options. As a starting point the donated biomaterial of registered patients will be analyzed firstly for the presence of a tumor predisposition by germline mutations. In case of detected genetic variations that are related to the tumor disease and which may affect the patient's health and follow-up care (because of the potentially increased risk of developing other malignant tumors), affected patients will be informed and referred to genetic counseling. Registry patients will be asked at the time of diagnosis if they wish to be informed about germline variants detected as part of the study procedures.
Conditions
Conditions (26)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Sarcoma | Bone Sarcoma | ONTOLOGY_EXACT | 0.98 |
| Bone Tumor | Bone Neoplasm | ALIAS | 0.90 |
| Chondroblastic Osteosarcoma | Chondroblastic Osteosarcoma | ONTOLOGY_EXACT | 0.98 |
| Clear Cell Osteosarcoma | — | UNRESOLVED | — |
| Conventional Central Osteosarcoma of Bone | — | UNRESOLVED | — |
| Conventional Osteosarcoma | Conventional Osteosarcoma | ONTOLOGY_EXACT | 0.98 |
| Extraskeletal Osteosarcoma | Extraskeletal Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
| Fibroblastic Osteosarcoma | Fibroblastic Osteosarcoma |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Data Collection
- timeFrame
- 20 years (There will be continous subgroup analyses through study completion.)
- description
- Aims of the registry are the collection of clinical data to gain further insights about diagnosis, treatment, prognosis and risk factors of osteosarcoma and biologically related bone tumors.
Secondary outcomes (2)
- measure
- Reference Diagnostics
- timeFrame
- 20 years (Recruitment period)
- description
- Aim of the registry is to give the frame for reference diagnostics.
- measure
- Collection of biologic samples.
- timeFrame
- 20 years (Recruitment period)
- description
- Aim of the registry is the collection of biomaterial.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * high-grade osteosarcoma (conventional and non-conventional) * parosteal, periosteal or extraosseous osteosarcoma * low grade central osteosarcoma * (osseous) Undifferentiated pleomorphic sarcoma (UPS) * (osseous) leiomyosarcoma * (osseous) dedifferentiated chondrosarcoma * (osseous) mesenchymal chondrosarcoma * (osseous) fibrosarcoma * (osseous) angiosarcoma * informed consent Exclusion Criteria: * no informed consent
References
Publications (0)
Data not yet available