Clinical trial · Interventional
Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi
Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi: A Mixed Methods Non-randomized Cluster Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 11, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260911-000001
Summary
Brief summary (as posted)
This study will evaluate the implementation of an enhanced package of care, CD4 and tuberculosis lipoarabinomannan (TB-LAM) tests and the initiation of patients on TB prophylaxis \[TPT and CPT\], on retention in care and viral suppression ((\<50 copies/ml) at 6 and 12 months after AHD care and treatment enrollment. The study will also assess the change in AHD screening, management and service uptake indicators among PLHIV clients before and after implementation of the QI collaborative implementation (QICI) project, evaluate the acceptability and feasibility of the AHD package of care among patients and HCWs providing related health services, and conduct a cost analysis of implementing the enhanced AHD package of care in a hub-and-spoke implementation of care model.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| AIDS and Infections | — | UNRESOLVED | — |
| AIDS-related Kaposi Sarcoma | AIDS-Related Kaposi Sarcoma | ONTOLOGY_EXACT | 0.98 |
| AIDS With Tuberculosis | — | UNRESOLVED | — |
| Cryptococcal Infections | — | UNRESOLVED | — |
| Opportunistic Infections, HIV-Related | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enhanced package for AHD care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Control
- description
- standard of care
- type
- EXPERIMENTAL
- label
- Intervention
- description
- Enhanced package of AHD care
- interventionNames
- Other: Enhanced package for AHD care
Primary outcomes (2)
- measure
- Proportion of AHD patients alive and retained in care
- timeFrame
- 6 and 12 months after initiation on ART after AHD diagnosis
- description
- Number of AHD patients alive and retained in care divided by the number of AHD patients initiated on antiretroviral therapy (ART) after diagnosis of AHD
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: HIV-infected clients (all ages) meeting the WHO definition for AHD: * CD4 count of \<200c/mm3 * or WHO clinical stage 3 or 4 * or children under the age of 5 on treatment for less than 12 months or unstable on treatment after 12 months Exclusion Criteria: * None
References
Publications (1)
- DERIVEDKatirayi L, Maphosa T, Chilikutali L, Chamanga RK, Petersson J, Khatib S, Munthali B, Nyirenda R, Matiya E, Nyirenda L, Tiam A, Denoeud-Ndam L. Understanding gender differences of people with HIV newly diagnosed or returning to care with advanced HIV disease in Malawi: a qualitative study. BMC Public Health. 2023 Dec 1;23(1):2382. doi: 10.1186/s12889-023-17384-y. PMID 38041058