Clinical trial · Interventional
Diagnostic Cervical Conization for Persistent Infection or Integration of HPV
A Study of the Value of Diagnostic Cervical Conization for Persistent Infection or Integration of Human Papillomavirus
NCT05510830CI-TRIAL-00060733not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia/cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Cervical Conization | — | UNRESOLVED | — |
| Cervical Intraepithelial Neoplasia | Cervical Intraepithelial Neoplasia | ONTOLOGY_EXACT | 0.98 |
| Human Papilloma Virus Infection | — | UNRESOLVED | — |
| Human Papilloma Virus Integration | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| diagnostic cervical conization | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients
- description
- The patients who meet the inclusion criteria will receive diagnostic cervical conization for pathological examinations. Then they will be followed up for at least two years with every six months' return to our clinics to test HPV and colposcopy if necessary.
- interventionNames
- Procedure: diagnostic cervical conization
Primary outcomes (2)
- measure
- The incidence of discovering concealed cervical cancer or percancerous lesions
- timeFrame
- up to 2 months after recruited
- description
- The pathological examinations of the cervical conization might discover some concealed cervical cancer or precancerous lesions which could not be discovered by biopsy guided by colposcopy.
- measure
- The incidence of HPV clearance after the cervical conization
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 25 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology. 2. The cervical precancerous lesions are highly suspected by clinicians with one or more following risk factors: * The course of HPV type 16/18 persistent infection is more than two years. * The integration reads of HPV is more than 15. * The impression of colposcopy indicates precancerous lesions. * The cervical TCT indicates ASC-H/HSIL/SCC/AGC-FN/AIS/AC. Exclusion Criteria: 1. Pregnant women. 2. Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations. 3. The patients are suffering malignant tumors of other system and have not been cured. 4. There is acute inflammation of the lower genital or anal tract. 5. The patients' health will be severely harmed by the colposcopy and cervical conization due to some circumstances such as severe insufficiency of liver and kidney function, blood diseases and acute inflammation of other systems.
References
Publications (0)
Data not yet available
No reference posted for this study.