Clinical trial · Interventional
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer
NCT05504265CI-TRIAL-00087478unknownPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| NSAIDs | — | UNRESOLVED | — |
| Opioid | — | UNRESOLVED | — |
| Patient-controlled Analgesia | — | UNRESOLVED | — |
| Perioperative Analgesia | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Patient-controlled analgesia pump | Device | — | UNRESOLVED |
| Postoperative flurbiprofen axetil | Drug | — | UNRESOLVED |
| Preemptive flurbiprofen axetil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- Postoperative NSAIDs
- interventionNames
- Drug: Postoperative flurbiprofen axetil
- type
- EXPERIMENTAL
- label
- Preemptive analgesia followed by Postoperative NSAIDs
- interventionNames
- Drug: Preemptive flurbiprofen axetil
- Drug: Postoperative flurbiprofen axetil
- type
- EXPERIMENTAL
- label
- Postoperative patient-controlled analgesia pump
- interventionNames
- Device: Patient-controlled analgesia pump
Primary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * 18-75 years; * Patients underwent laparoscopic and thoracoscopic or robotic-assisted minimally invasive esophagectomy ; * Informed consent. Exclusion Criteria: * Has a history of cholecystitis or urolithiasis within 3 months; * Has a history of atherothrombosis (peripheral arterial disease), stroke, myocardial infarction; * With lung diseases, such as pneumonia, atelectasis, emphysema, pulmonary bullae, etc; * Preoperative cardiac function grade ≥ III or coronary artery stenosis; * Preoperative indwelling of a thoracic drainage tube; * Long-term heavy drinker(heavy drinking was defined as follows: for men, consuming more than 4 drinks on any day or more than 14 drinks per week; For women, consuming more than 3 drinks on any day or more than 7 drinks per week); * Opioid-tolerant patients(defined as those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid); * With painful skin complications, such as rashes and blisters; * Conversion to open surgery; * The postoperative ventilation function was limited, or the duration of endotracheal intubation was more than 24h.
References
Publications (0)
Data not yet available
No reference posted for this study.