Clinical trial · Interventional
Dexmedetomidine Infusion on Intraoperative Propofol,Fentanyl Requirements in Spine Surgery for Pediatric Cancer Patients
the Role of Dexmedetomidine (Precedex) Infusion on Intraoperative Propofol & Fentanyl Requirements in Spine Surgery for Pediatric Cancer Patients
NCT05493228CI-TRIAL-00060220unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this trial is to investigate whether the effect of a low-dose dexmedetomidine infusion will decrease propofol consumption or not through a double blinded randomized controlled trial done in children cancer hospital 57357.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia | — | UNRESOLVED | — |
| Spine Cancer | Malignant Spinal Cord Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Precedex Injectable Product | Drug | — | UNRESOLVED |
| Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- patient is receiving dexmedetomidine
- description
- dexmedetomidine infusion at the rate of 0.5 μg kg-1 hr-1, started after the induction of general anesthesia without a loading dose
- interventionNames
- Drug: Precedex Injectable Product
- type
- PLACEBO_COMPARATOR
- label
- standard treatment (saline)
- description
- saline injection only after the induction of general anesthesia
- interventionNames
- Drug: Saline
Primary outcomes (4)
- measure
- Rate of propofol infusion per hour
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * spinal cord tumor resection based on magnetic resonance imaging (MRI) studies. * age between 5 -18 years old * American Society of Anesthesiologists (ASA) physical status II or III. Exclusion Criteria: * Emergency spine surgery * Cardiac patients * Any individual with stage 4 or greater chronic kidney disease (eGFR\< 30 ml/min) and/or requiring dialysis * liver failure defined as a history of cirrhosis or fulminant hepatic failure * Preoperative dexmethatodine use * Preoperative systolic hypertension defined by a systolic blood pressure greater than 130 mmHg in the surgical admission suite * Enrolled in another study within 30 days.
References
Publications (0)
Data not yet available
No reference posted for this study.