Clinical trial · Observational
Translational Research Center in Lung Cancer Disparities (TRACER) Project 2
Biological Pathways in Stress Reactivity and Nicotine Addiction Among African American and White Smokers
NCT05490251CI-TRIAL-00113417TRACERcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Smoking | — | UNRESOLVED | — |
| Smoking Behaviors | — | UNRESOLVED | — |
| Smoking Cessation | — | UNRESOLVED | — |
| Stress Reaction | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Examining racial differences in acute stress responses
- timeFrame
- Within 1 month following baseline
- description
- Examine racial differences in acute stress responses using a validated psychological stress challenge called the Trier Social Stress Test (TSST)
- measure
- Examining changes in daily cortisol patterns according to race
- timeFrame
- Baseline, 4- and 8 weeks post Trier Social Stress Test laboratory visit
- description
- Examine racial differences in daily diurnal cortisol slopes to evaluate hypothalamic-pituitary-adrenal-axis dysregulation and acute stress
- measure
- Examine changes in stress responses and smoking behaviors as it relates to social determinant factors
- timeFrame
- Baseline, 4- and 8-weeks post Trier Social Stress Test laboratory visit
- description
- Patients will be administered a survey using validated measures to examine socioeconomic, structural, and psychosocial stressors that impact daily stress and smoking behaviors
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * African American and white males * Between the ages of 18-75 years old * Smoke at least 5 to 10 cigarettes per day Exclusion Criteria: * Smokers who have a serious cognitive disorder * Have a personal history of lung cancer * Personal history of usage of illicit drug and alcohol abuse * Enrollment in a smoking cessation treatment program during the past 6 months * Current use of a nicotine replacement therapy * Have any positive responses on the Mini International Neuropsychiatric Interview (MINI) screener
References
Publications (0)
Data not yet available
No reference posted for this study.