Clinical trial · Observational
Transnasal Esophagoscopy (TNE) Esophageal Cancer Screening
Repurposing Transnasal Esophagoscopy: Targeting Interventions for a Community That Has Been Targeted for Cancer Risk
NCT05480891CI-TRIAL-00090156terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Transnasal Esophagoscopy (TNE) scope is no longer manufactured so the study is unable to be continued.
Summary
Brief summary (as posted)
This research study is being done for 2 reasons: 1) The investigators want to learn about the eating, smoking and drinking habits of adults, 18 years of age and older, in various Chicago communities, and 2) the investigators want to offer screening for participants whose smoking and drinking habits put them at risk for cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Transnasal Esophagoscopy (TNE) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Conduct a population survey of UI Health and Mile Square Community Center patients focusing on specific risk factors associated with esophageal squamous cell carcinoma (ESCC)
- timeFrame
- Through study completion, an average of 2 years
- description
- The researchers will collect data on the consumption of alcohol and tobacco as they are known risk factors for ESCC. The researchers will specifically assess consumption of fortified wines and mentholated cigarettes based on the targeted marketing of these products in identified communities. The researchers will also assess consumption of fresh fruits and vegetables and proportion of fat in dietary consumption to assess whether these conditions are associated with cancer risk.
- measure
- Develop risk/screening criteria for esophageal squamous cell carcinoma in at risk populations
- timeFrame
- Through study completion, anticipating 2 years
- description
- The researchers hope our data will serve to help create a risk stratification that can parallel current guidelines for screening patients for adenocarcinoma (which primarily affects Caucasian males). The researchers will compare results of trans-nasal esophagoscopy (TNE) exam and any biopsy specimens collected with the risk profile generated by survey results.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Male and female patients 18 years of age or older * Patients being seen at one of the UI Health Centers for an ear, nose, or throat related concern. * Patients who have a history of both smoking and drinking. * Patients must be willing to complete a study survey. * Patients must understand the purpose and procedures of the study and be willing to participate. * Patients who speak English. * All adult men and women who meet the study criteria will be asked to participate in the study without regard to race, gender or socioeconomic status. * For Part 2 of the study, inclusion criteria includes all patients 40 and over with a history or smoking and drinking as well as patients 18 years of age and older who present with dysphasia and/or pain when swallowing. Patients eligible for Part 2 of the study will be informed of the study, but they will not be consented during their clinic visit. Exclusion Criteria: * Male and Female patients under the age of 18. * Patients who are not being seen at one of the UI Health Community Health * Centers for an ear, nose or throat related concern. * Patients who do not have a history of both drinking and smoking. * Patients unwilling to complete the study survey. * Women who are pregnant will be excluded from both Part 1 and Part 2 of the study. * Patients unable to understand the purpose and procedures of the study and/or who are not willing to participate. * Patients who do not speak English. Excluded or Vulnerable Populations * Minors will be excluded from the study because they are not at risk for the factors being studied in the research. * Subjects who are not English speaking will be excluded due to the limited capacity of the primary investigators to obtain informed consent in this population.
References
Publications (0)
Data not yet available
No reference posted for this study.