Clinical trial · Observational
Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes
Indications, Trends, and Perioperative Outcomes of Minimally Invasive and Open Liver Surgery in Non-obese and Obese Patients: an International Multicentre Propensity Score Matched Retrospective Cohort Study of 9963 Patients.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Liver Metastases | — | UNRESOLVED | — |
| Obesity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Minimally invasive liver resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Open liver resection
- description
- Non-obese or obese patients that underwent an open liver resection for all indications
- label
- Minimally invasive liver resection
- description
- Non-obese or obese patients that underwent a minimally invasive liver resection for all indications
- interventionNames
- Procedure: Minimally invasive liver resection
Primary outcomes (1)
- measure
- Major complications
- timeFrame
- 30 days postoperatively
- description
- Severe complications (Clavien-Dindo grade 3a or higher) related to the surgical procedure
Secondary outcomes (13)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 18 years and older * Patients that have undergone an elective minimally invasive or open liver resection Exclusion Criteria: * Patients that have undergone a hand-assisted or robotic procedure * Patients with a BMI lower than 18.5
References
Publications (0)
Data not yet available