Clinical trial · Observational
Perioperative Outcomes of Simultaneous Colorectal and Liver Resections
Simultaneous Resection of Colorectal Cancer and Synchronous Liver Metastases: What Determines the Risk of Unfavorable Outcomes? A Retrospective International Multicenter Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades. However, it remains unclear when a simultaneous resection is beneficial and when it should be avoided. The objective of this retrospective study is therefore to compare the outcomes of a simultaneous resection for synchronous colorectal liver metastases in different settings, and to assess which factors are independently associated with unfavorable outcomes.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer Metastatic | Colorectal Neoplasm | PROBABILISTIC | 0.70 |
| Surgical Procedure, Unspecified | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Major liver resection | Procedure | — | UNRESOLVED |
| Technically major liver resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Minor liver resection
- description
- Minor liver resection (\<3 contiguous segments) in the anterolateral segments
- label
- Technically major liver resection
- description
- Minor liver resection (\<3 contiguous segments) in the posterosuperior segments (Segment 1,4a,7,8)
- interventionNames
- Procedure: Technically major liver resection
- label
- Major liver resection
- description
- Major liver resection (3 or more contiguous segments)
- interventionNames
- Procedure: Major liver resection
Primary outcomes (1)
- measure
- Major complications
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Elective minimally invasive or open simultaneous resection of colorectal cancer and synchronous colorectal liver metastases Exclusion Criteria: * (Partially) robotic-assisted or thoracoscopic procedures * First stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) * Patients that underwent major concurrent procedures
References
Publications (1)
- DERIVEDSijberden JP, Zimmitti G, Conci S, Russolillo N, Masetti M, Cipriani F, Lanari J, Gorgec B, Benedetti Cacciaguerra A, Rotellar F, D'Hondt M, Edwin B, Sutcliffe RP, Dagher I, Efanov M, Lopez-Ben S, Primrose JN, Giuliante F, Spinelli A, Chand M, Alvarez S, Langella S, Nicosia S, Ruzzenente A, Vivarelli M, Cillo U, Aldrighetti L, Jovine E, Ferrero A, Guglielmi A, Besselink MG, Abu Hilal M. Simultaneous resection of colorectal cancer and synchronous liver metastases: what determines the risk of unfavorable outcomes? An international multicenter retrospective cohort study. Int J Surg. 2023 Mar 1;109(3):244-254. doi: 10.1097/JS9.0000000000000068. PMID 37093069