Clinical trial · Interventional
Intraoperative Sonographically Guided Resection of Non-enhancing Gliomas
Intraoperative Sonographically Guided Resection of Gliomas Not Enhancing Contrast Agent in Magnetic Resonance Imaging: a Randomised, Controlled Trial
NCT05470374CI-TRIAL-00089813SONOGLIOsuspendedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): technical issues
Summary
Brief summary (as posted)
The purpose of the study is to determine whether intraoperative ultrasound guided resection of glioma without contrast enhancement in magnetic resonance imaging can achieve higher extent of resection than surgery without intraoperative sonography
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-enhancing Cerebral Gliomas | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intraoperative sonography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Ultrasound
- description
- Glioma resection with intraoperative sonography
- interventionNames
- Procedure: Intraoperative sonography
- type
- NO_INTERVENTION
- label
- Non-ultrasound
- description
- Glioma resection without intraoperative sonography
Primary outcomes (1)
- measure
- Extent of resection in percents
- timeFrame
- within 48 hours after surgery
- description
- Extent of resection = (preoperative tumor volume - postoperative tumor volume) / preoperative tumor volume x 100
Secondary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * single supratentorial gliomas without contrast enhancement in preoperative magnetic resonance imaging (presumed low-grade gliomas) * newly diagnosed * previously untreated * Karnofsky Performance Status 60-100% * age 18-79 years * performed magnetic resonance imaging with contrast enhancement Exclusion Criteria: * glioma spreading to brainstem * previously performed radiotherapy, chemotherapy or immunotherapy * planned supratotal tumor resection until neurophysiologically revealed eloquent areas
References
Publications (0)
Data not yet available
No reference posted for this study.