Clinical trial · Interventional
Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions. Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Metastases | Brain Neoplasm | PROBABILISTIC | 0.70 |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Additional CEST sequences during PET/MRI exam | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients with glioma or brain metastases
- interventionNames
- Other: Additional CEST sequences during PET/MRI exam
Primary outcomes (2)
- measure
- Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases
- timeFrame
- through study completion, up to 14 years
- description
- Evaluation at the cerebral level on the acquisition images of residual volume in MRI
- measure
- Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases
- timeFrame
- through study completion, up to 14 years
- description
- Evaluation at the cerebral level on the acquisition images of tumoral metabolic activity in PET
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Patients admitted to the Nuclear Medicine and Molecular Imaging department of ICANS (Institut de cancérologie strasbourg Europe) for a PET/MRI exam dedicated to: * Preoperative evaluation of a cerebral expansion lesion * Evaluation of glioma recurrences * Evaluation of brain metastases * Evaluation of recurrence of metastases Exclusion Criteria: * Contraindication to the realization of an MRI * Minor or patients placed under guardianship or supervision * Patients deprived of liberty * Patients placed under judicial protection * Patients that are not able to express their consent * Pregnant and breastfeeding women
References
Publications (0)
Data not yet available