Clinical trial · Observational
Liquid Biopsy for Early Non-small Lung Cancer Detection
Liquid Biopsy to Distinguish Malignant From Benign Pulmonary Nodules and to Monitor Response to Therapy
NCT05462795CI-TRIAL-00083763completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial will assess the performance of a liquid biopsy assay to identify cancer in indeterminant pulmonary nodules identified by CT screening of high-risk individuals and evaluate the capability of the liquid biopsy assay to monitor response to surgical resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Small-cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Liquid biopsy for aberrant DNA methylation analysis - Benign lung disease | Diagnostic Test | — | UNRESOLVED |
| Liquid biopsy for aberrant DNA methylation analysis - Healthy volunteer | Diagnostic Test | — | UNRESOLVED |
| Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule | Diagnostic Test | — | UNRESOLVED |
| Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Indeterminate pulmonary nodule study cohort
- description
- Patients undergoing a biopsy of an indeterminate lung nodule by surgical excision, bronchoscopic biopsy or Interventional Radiology directed biopsy
- interventionNames
- Diagnostic Test: Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule
- label
- Known lung cancer for surgical resection study cohort
- description
- Patients with known non-small cell lung cancer who will have surgical resection for treatment
- interventionNames
- Diagnostic Test: Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection
- label
- Healthy volunteer cohort
- description
- Healthy volunteers with a) no current diagnosis of cancer; b) no history of cancer over the last 5 years; and c) no existing known benign lung disease that is currently requiring treatment with medication.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Indeterminate pulmonary nodule study cohort * Inclusion criteria: Patients undergoing a biopsy of an indeterminate lung nodule by surgical excision, bronchoscopic biopsy or Interventional Radiology directed biopsy * Exclusion criteria: No known concurrent cancer Known lung cancer for surgical resection study cohort * Inclusion criteria: Patients with known non-small cell lung cancer who will have surgical resection for treatment * Exclusion criteria: N/A Healthy volunteer cohort * Inclusion criteria: Healthy persons * Exclusion criteria: No known current cancer or history of cancer within 5 years Benign lung disease cohort * Inclusion criteria: Patients with the following categories of benign lung disease: COPD/emphysema, Granulomatous infection, Interstitial lung disease including pulmonary fibrosis and interstitial lung disease. * Exclusion criteria: N/A
References
Publications (0)
Data not yet available
No reference posted for this study.