Clinical trial · Observational
Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis
NCT05462470CI-TRIAL-00059706completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Liver Metastases | Colorectal Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-Repeat Liver Surgery | Procedure | — | UNRESOLVED |
| Repeat Liver Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- repeat liver surgery
- description
- repeat liver surgery for liver relapse lesions
- interventionNames
- Procedure: Repeat Liver Surgery
- label
- non-repeat liver surgery
- description
- non-repeat liver surgery, just only systemic palliative chemotherapy
- interventionNames
- Procedure: Non-Repeat Liver Surgery
Primary outcomes (1)
- measure
- overall survival
- timeFrame
- 5 years
- description
- Overall survival after the first resection of liver metastatic lesions
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * initially unresectable colorectal liver metastasis (IU-CRLM) * received conversion therapy * underwent conversion hepatectomy Exclusion Criteria: * the histologic type of CRLM was not called adenocarcinoma * uncontrollable extrahepatic metastases, such as peritoneal, bone, brain metastasis * history of previous hepatectomy * the primary tumor was not resected or palliative resection * R1 or R2 liver resection
References
Publications (0)
Data not yet available
No reference posted for this study.