Clinical trial · Observational
Intra-arterial Perfusion in Interventional Radiology
Application of Intra-arterial CT Perfusion During Interventional Radiology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients are being asked to participate in a study to better determine blood flow going to tumors in the liver. They will undergo an embolization procedure in interventional radiology where the goal is to provide treatment directly into the liver tumor. These treatments are delivered into the blood vessels feeding the tumors. Improving these treatments relies on better understanding the blood flow into the tumor. By understanding how much blood flows into the tumors, the goal is to make sure there is the best chance of killing the tumor. The investigators are attempting to use a special type of CT scan during the procedure to determine the blood flow to the tumors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intra-arterial Perfusion | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Standard Dose Intra-arterial Perfusion
- description
- All patients will undergo standard of care interventional treatment for liver cancer. The procedure will take place utilizing fluoroscopic and CT guidance. During their procedure, patients will have intra-arterial CT perfusion maps derived of the liver including the region of the tumor. (n=10)
- interventionNames
- Device: Intra-arterial Perfusion
- label
- Low Dose Intra-arterial Perfusion
- description
- Investigate the impacts on contrast and radiation doses and the robustness of reconstruction algorithms on intra-arterial CT perfusion using a lower radiation dose technique. (N=10)
- interventionNames
- Device: Intra-arterial Perfusion
Primary outcomes (1)
- measure
- Quantification of Parameters for Intra-arterial Perfusion
- timeFrame
- 1 Day to 1 year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age \> or = 18 years 2. primary or secondary liver tumor(s) 3. Trans-arterial chemoembolization (TACE) or trans-catheter radio embolization (TARE) approved by multidisciplinary tumor board 4. Tumor in an area without prior surgical or ablative therapy 5. At least 1 tumor greater than 1.5 cm in greatest diameter Exclusion Criteria: 6. Not eligible for TACE procedure. 7. Same additional exclusion criteria as aim 1 8. Any residual ethiodized oil accumulation in the liver 9. No prior IA treatment in the last year
References
Publications (1)
- BACKGROUNDMoawad AW, Szklaruk J, Lall C, Blair KJ, Kaseb AO, Kamath A, Rohren SA, Elsayes KM. Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging. J Hepatocell Carcinoma. 2020 Apr 23;7:77-89. doi: 10.2147/JHC.S224471. eCollection 2020. PMID 32426302