Clinical trial · Interventional
Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Squamous cell carcinoma (SCC) is the most common oral cavity carcinoma. Conventional therapeutic modalities for oral malignancy include surgery, radiotherapy and chemotherapy alone or in combinations.The major obstacle of using current anticancer drugs is; first the non-specific tissue distribution, as these drugs are unable to distinguish between normal and cancer cells.Quercetin is a bioactive flavonoid having strong antioxidant properties. .Among all the nanomaterials, polymeric nanoparticles are of significant interest for drug delivery applications due to many unique features of nanoparticle polymers.This is the first study to investigate the anticancer effects of (Quercetin) either free or encapsulated by PLGA-PEG NPs in tongue squamous cell carcinoma (TSCC) cell line.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Doxorubicin chemotherapeutic drug as a positive control | Drug | — | UNRESOLVED |
| Quercetin 3,3',4',5,6-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one | Drug | — | UNRESOLVED |
| Quercetin-encapsulated PLGA-PEG nanoparticles (Nano-QUT) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Quercetin drug.
- interventionNames
- Drug: Quercetin 3,3',4',5,6-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
- type
- EXPERIMENTAL
- label
- Quercetin-encapsulated PLGA-PEG nanoparticles
- interventionNames
- Drug: Quercetin-encapsulated PLGA-PEG nanoparticles (Nano-QUT)
- type
- ACTIVE_COMPARATOR
- label
- Doxorubicin chemotherapeutic drug
- interventionNames
- Drug: Doxorubicin chemotherapeutic drug as a positive control
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Tongue Squamous cell carcinoma cell lines * Quercetin drug. * Quercetin-encapsulated PLGA-PEG nanoparticles (Nano-QUT) * Application of a Quercetin drug as chemotherapeutic drug. * Detection of Quercetin activity in apoptosis or cytotoxicity/cell viability. Exclusion Criteria: * Any cancer cell line other than tongue Squamous cell carcinoma cell lines * Any use of Quercetin other than chemotherapy. * Detection of Quercetin activities other than apoptosis or cytotoxicity/cell viability
References
Publications (0)
Data not yet available