Clinical trial · Observational
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma; a National Cancer Database Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Appendiceal Cancer | Malignant Appendix Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hemicolectomy | Procedure | — | UNRESOLVED |
| Partial colecctomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Partial colectomy
- description
- Patients with appendiceal cancer who underwent segmental resection of appendiceal adenocarcinoma
- interventionNames
- Procedure: Partial colecctomy
- label
- Hemicolectomy
- description
- Patients with appendiceal cancer who underwent formal right hemicolectomy of appendiceal adenocarcinoma
- interventionNames
- Procedure: Hemicolectomy
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 60 months
- description
- Percent of patients who were alive at five years of follow-up
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection Exclusion Criteria: * Patients with other pathologic types of appendiceal cancer * Patients with clinical stage IV or unknown stage * Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery
References
Publications (0)
Data not yet available