A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPC

Inclusion Criteria:

* patients clinically diagnosed OME after radiotherapy for NPC (diagnostic criteria: have fluid drained from tympanic cavity during tympanocentesis) , who had completed radiotherapy for ≥6 months, and had failed to respond after two or more times of tympanocentesis
* Eustachian Tube Dysfunction Questionnaire score greater than 14
* clinical findings of a retracted drum
* fluid behind the drum
* tympanometry type B or C results
* patients volunteered to participate in the study and signed the informed consent
* patients volunteered to bear the corresponding costs of surgery and consumables.

Exclusion Criteria:

* NPC recurrence or other malignant tumor after radiotherapy
* a perforated tympanic membrane
* the presence of a ventilation tube
* a period of less than six months following the final radiotherapy treatment
* clear diagnosis of Eustachian ostium atresia or nasal obstruction diseases, such as severe deviated nasal septum, nasal polyp, choanal atresia, osteoradionecrosis of skull base after radiotherapy, etc.
* patients with severe underlying diseases could not tolerate general anesthesia
* patients who could not cooperate (including poor hearing and radiation encephalopathy)
* patients with other middle ear diseases, such as middle ear cholesteatoma, osteoradionecrosis of temporal bone after radiotherapy, etc.
* severe deglutition disorders
* cleft palate