Clinical trial · Interventional
Breaking Through the Brain Fog: An Online Research Study
Breaking Through the Brain Fog: An Online RCT for Breast Cancer Survivors
NCT05444231CI-TRIAL-00090662completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will investigate the benefits of distinct brain health trainings in breast cancer survivors (age 30-80) with cognitive concerns post-chemotherapy. This study can be completed from the comfort of participant's own home.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer Female | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Brain Training A | Behavioral | — | UNRESOLVED |
| Brain Training B | Behavioral | — | UNRESOLVED |
| Brain Training C | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Brain Training A
- description
- This group will access one type of online brain-health oriented training.
- interventionNames
- Behavioral: Brain Training A
- type
- ACTIVE_COMPARATOR
- label
- Brain Training B
- description
- This group will access a distinct type of online brain-health oriented training.
- interventionNames
- Behavioral: Brain Training B
- type
- ACTIVE_COMPARATOR
- label
- Brain Training C
- description
- This group will access a distinct type of online brain-health oriented training.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Female breast cancer survivors who... * are between ages of 30-80 * were diagnosed with Stage I-III * received chemotherapy * completed chemotherapy at least 6 months ago but not more than 5 years * endorse changes in thinking since end of chemotherapy treatment * have working internet and a device * consider themselves fluent in English Exclusion criteria: * Males * A re-occurrence of breast cancer or a diagnosis of another * An uncorrected hearing or vision issue that would hinder ability to read and/or listen to training material * Participation in a cognitive training program in the last 12 months. * A reported substance abuse problem * Diagnosis of a neurodegenerative disease or psychotic disorder * History of stroke, concussion, or brain injury since completing chemotherapy * Inability to function independently due to Autism Spectrum Disorder diagnosis
References
Publications (11)
- BACKGROUNDChapman SB, Aslan S, Spence JS, Hart JJ Jr, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, DeFina LF, Lu H. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex. 2015 Feb;25(2):396-405. doi: 10.1093/cercor/bht234. Epub 2013 Aug 28. PMID 23985135
- BACKGROUNDChapman SB, Fratantoni JM, Robertson IH, D'Esposito M, Ling GSF, Zientz J, Vernon S, Venza E, Cook LG, Tate A, Spence JS. A Novel BrainHealth Index Prototype Improved by Telehealth-Delivered Training During COVID-19. Front Public Health. 2021 Mar 16;9:641754. doi: 10.3389/fpubh.2021.641754. eCollection 2021. PMID 33796498
- BACKGROUNDChapman SB, Mudar RA. Enhancement of cognitive and neural functions through complex reasoning training: evidence from normal and clinical populations. Front Syst Neurosci. 2014 Apr 28;8:69. doi: 10.3389/fnsys.2014.00069. eCollection 2014. PMID 24808834
- BACKGROUNDChapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D'Esposito M. Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci. 2016 Jul 18;10:338. doi: 10.3389/fnhum.2016.00338. eCollection 2016. PMID 27462210
- BACKGROUNDChapman SB, Spence JS, Aslan S, Keebler MW. Enhancing Innovation and Underlying Neural Mechanisms Via Cognitive Training in Healthy Older Adults. Front Aging Neurosci. 2017 Oct 9;9:314. doi: 10.3389/fnagi.2017.00314. eCollection 2017. PMID 29062276
- BACKGROUNDMotes MA, Yezhuvath US, Aslan S, Spence JS, Rypma B, Chapman SB. Higher-order cognitive training effects on processing speed-related neural activity: a randomized trial. Neurobiol Aging. 2018 Feb;62:72-81. doi: 10.1016/j.neurobiolaging.2017.10.003. Epub 2017 Oct 12. PMID 29121545
- BACKGROUNDHan K, Davis RA, Chapman SB, Krawczyk DC. Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury. Brain Behav. 2017 Apr 10;7(5):e00687. doi: 10.1002/brb3.687. eCollection 2017 May.