Clinical trial · Interventional
Efficacy and Safety of Herombopag in Patients With Thrombocytopenia Before Hepatectomy
Director, Department of Liver Surgery, Fudan University Shanghai Cancer Center
NCT05442632CI-TRIAL-00075023unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a single center, randomized, controlled study, to evaluate the efficacy and safety of Herombopag in patients with Thrombocytopenia before hepatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatopathy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hetrombopag | Drug | — | UNRESOLVED |
| Placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental: 1
- description
- durg:Hetrombopag 5mg,once daily,oral
- interventionNames
- Drug: Hetrombopag
- type
- EXPERIMENTAL
- label
- Experimental: 2
- description
- Ndurg: Placebo 5mg,once daily,oral
- interventionNames
- Drug: Placebo
Primary outcomes (1)
- measure
- The proportion of patients who require blood product infusion or intervention with platelet raising drugs due to bleeding during the perioperative period
- timeFrame
- From the start of using the investigational drug to 7 days after surgery completion
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 1\. Male and female subjects ≥18 years of age; * 2.Patients prepared to receive hepatectomy; * 3.50×10\^9/L≤platelet count≤80×10\^9/L; * 4.Child-PUgh score A or grade B (≤7 ); * 5.Life expectancy ≥3 months; * 6.Normal Bone marrow hematopoiesis and renal function; * 7.Voluntary participation and written informed consent; Exclusion Criteria: * 1.Central nervous system diseases caused by liver disease; * 2.Platelet transfusion within 7 days prior to the first dose of study drug; * 3.History of any primary hematologic disorder; * 4.History of arterial or venous thrombosis, including thrombosis of any part of the splenic-mesenteric system; * 5.Pre-diagnosed Immune Thrombocytopenic Purpura (ITP); * 6.History of Myelodysplastic Syndrome (MDS); * 7.Those with bleeding tendency,have evidence of hereditary bleeding or blood coagulation disorder; * 8.Females who are pregnant (positive β-hCG test ) or breastfeeding; * 9.Subjects who have participated in another investigational trial within 30 days prior to Visit 1; * 10.Those with uncontrollable neurological and psychiatric diseases or mental disorders, poor compliance, unable to cooperate and describe treatment response; * 11.Subjects with known intolerance or allergy to any of the ingredients in eltrombopag tablets;
References
Publications (0)
Data not yet available
No reference posted for this study.