Clinical trial · Interventional
Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial
NCT05440240CI-TRIAL-00066506recruitingPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Comparing percutaneous needle fasciotomy +/- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.
Conditions
Conditions (12)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Connective Tissue Diseases | — | UNRESOLVED | — |
| Contracture | — | UNRESOLVED | — |
| Dupuytren Contracture | Palmar Fibromatosis | ALIAS | 0.90 |
| Dupuytren's Disease | — | UNRESOLVED | — |
| Fibroma | Fibroma | ONTOLOGY_EXACT | 0.98 |
| Joint Diseases | — | UNRESOLVED | — |
| Musculoskeletal Diseases | — | UNRESOLVED | — |
| Neoplasm, Fibrous Tissue | Neoplasm | ONTOLOGY_EXACT | 0.85 |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Neoplasms by Histologic Type | — | UNRESOLVED | — |
| Neoplasms, Connective and Soft Tissue |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Corticosteroid injection | Drug | — | UNRESOLVED |
| Percutaneous needle fasciotomy | Procedure | — | UNRESOLVED |
| Saline injection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Corticosteroid injection
- description
- Percutaneous needle fasciotomy with corticosteroid injection
- interventionNames
- Procedure: Percutaneous needle fasciotomy
- Drug: Corticosteroid injection
- type
- PLACEBO_COMPARATOR
- label
- Saline injection
- description
- Percutaneous needle fasciotomy with saline injection
- interventionNames
- Procedure: Percutaneous needle fasciotomy
- Other: Saline injection
Primary outcomes (1)
- measure
- Recurrence rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Sufficient correction of metacarpophalangeal (MCP) joint during the PNF treatment, defined as \<20° passive extension deficit (PED), is a prerequisite for inclusion. Inclusion Criteria: * Dupuytren contracture (DC) of ≥ 20° PED in MCP joint measured with a goniometer * DC of either II-V finger * Well-defined/palpable cord Exclusion Criteria: * Legally incapacitated * Previous study inclusion with another finger ray * Isolated proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint contracture, defined as MCP joint contracture \< 20° PED regardless of the deficit in the PIP or DIP joint * Previous hand surgery of the affected finger for any reason * Known allergy to the study medication * Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion) * Pregnant or lactation * Insulin dependent diabetes mellitus * Ongoing systemic infection or local infection at the site of the procedure * Rheumatoid arthritis * Amyloidosis or mucopolysaccharidosis * Unable to communicate, cooperate or participate in follow-up
References
Publications (1)
- DERIVEDMatthiesen LH, Skov ST, Lange J. Adjuvant steroid to percutaneous needle fasciotomy for Dupuytren's contracture. An RCT study protocol. Dan Med J. 2024 Nov 12;71(12):A05240324. doi: 10.61409/A05240324. PMID 39749555