Clinical trial · Interventional
Partial Chest Wall Radiation Therapy After Surgery for Lymph Node Negative Breast Cancer
Prospective Pilot Study of Partial Chest Wall Radiation Therapy (PCWRT) for Positive or Close Margins After Modified Radical Mastectomy for Lymph Node-Negative Breast Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No eligible participants identified
Summary
Brief summary (as posted)
The standard treatment for breast cancer when cancer cells were found near or within the margins of the tissue that is removed during breast surgery, is radiation of the entire chest wall. This may be considered overtreatment since the only reason for doing so is that cancer cells were near or in the margins of the breast tissue that was removed. In this study, the amount of radiation treatment will be limited to the area where the remaining cancer cells were found after surgery. The purpose of this study is to find out if partial chest wall radiation therapy is as good as whole chest wall radiation therapy in reducing the risk of breast cancer cancer coming back.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Breast Cancer Female | — | UNRESOLVED | — |
| DCIS | Breast Ductal Carcinoma In Situ | ALIAS | 0.90 |
| Stage I Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
| Stage II Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Partial Chest Wall Radiation Therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Radiation Treatment
- interventionNames
- Radiation: Partial Chest Wall Radiation Therapy
Primary outcomes (4)
- measure
- Breast cancer recurrence
- timeFrame
- 5 years
- description
- Number of patients with recurrent breast cancer
- measure
- Acute toxicity
- timeFrame
- 3 months
- description
- Frequency of radiation-related adverse events
- measure
- Delayed toxicity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * DCIS or stage T1 or T2 invasive breast cancer, lymph node negative * Must have undergone mastectomy * Presence of cancer cells on or close to surgical margins * Negative pregnancy test for women * Must receive radiation at Stony Brook University Hospital Exclusion Criteria \- Received prior radiation to are to be irradiated
References
Publications (0)
Data not yet available