Clinical trial · Interventional
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Transversus Abdominis Plane Blocks With and Without Dexamethasone: A Randomized Clinical Trial in Minimally Invasive Colorectal Surgery
NCT05432934CI-TRIAL-00072057TAP-DEXunknownPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Disorders | — | UNRESOLVED | — |
| Crohn Disease | — | UNRESOLVED | — |
| Diverticular Diseases | — | UNRESOLVED | — |
| Local Anesthetic Complication | — | UNRESOLVED | — |
| Pain, Postoperative | — | UNRESOLVED | — |
| Regional Anesthesia Morbidity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone | Drug | Dexamethasone | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dexamethasone
- description
- Dexamethasone 16mg will be added to local anesthetic solution for TAP blocks. 4mg will be injected at 4 anterior abdominal wall sites in a laparoscopically-administered TAP block. This is a single intraoperative dose.
- interventionNames
- Drug: Dexamethasone
- type
- NO_INTERVENTION
- label
- Local anesthetic only
- description
- Local anesthetic (bupivacaine 0.25) 1mL/kg will be used for TAP blocks.
Primary outcomes (1)
- measure
- Total postoperative opioid consumption in the first 48 hours after surgery (hydromorphone equivalents.
- timeFrame
- 48 hours
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age \> 18 * ASA class I-III * elective or urgent inpatient laparoscopic/laparoscopic assisted colorectal surgery. Exclusion Criteria: * emergency surgery * open surgery * contraindications to laparoscopic surgery (ie. adhesions, inability to tolerate pneumoperitoneum) * ASA class 4 * age \< 18 * pregnant or breastfeeding women * significant cardiorespiratory/hepatic/renal disease * allergy to any study drugs * inability to consent * inability to respond to pain assessments * inability to use the patient-controlled analgesia device (PCA) * preoperative chronic opioid use
References
Publications (0)
Data not yet available
No reference posted for this study.