Clinical trial · Observational
Prediction of Chemotherapy Toxicity and Survival in Elderly Cancer Patients by CARG Score
Prediction of Chemotherapy Toxicity and Survival in Elderly Cancer Patients by Using CARG Score (Cancer and Aging Research Group Score)
NCT05432726CI-TRIAL-00059730unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prediction of chemotherapy toxicity and survival in elderly (aged ≥65 years old) patients with advanced solid tumors receiving systemic chemotherapy by using CARG risk score.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Solid Tumors ,Adults | Solid Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| calculating CARG score | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Elderly patients
- description
- Elderly patients (aged ≥65 year's old) planned to receive first-line chemotherapy for advanced solid tumor malignancies, presenting to the clinical oncology department, Assiut University Hospitals, Assiut, Egypt.
- interventionNames
- Other: calculating CARG score
Primary outcomes (1)
- measure
- Prediction of grade 3-5 chemotherapy toxicity risk in elderly patients (aged ≥65 years old) with advanced solid tumors by measurement of CARG risk score (Cancer and Aging Research Group).
- timeFrame
- 6 months follow up in first line chemotherapy in the advanced setting
Secondary outcomes (3)
- measure
- Correlation of the physician measured ECOG PS with grade 3-5 toxicities.
- timeFrame
- 6 months follow up in first line chemotherapy in the advanced setting
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age: ≥65 years. * Sex: male, female. * ECOG performance status 0,1,2 * Type of malignancy: solid tumor malignancies planned for systemic chemotherapy alone. * Stage: Advanced stage (metastatic first line, recurrent, unresectable locally advanced). * Type of Systemic therapy: chemotherapy alone not combined with immunotherapy or radiotherapy. * Able to comprehend and complete questionnaire. Exclusion Criteria: * Receiving concurrent radiotherapy or immunotherapy. * ECOG performance status \>2.
References
Publications (4)
- RESULTMoth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, Stockler MR, Beale P, Blinman P. Oncologists' perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. J Geriatr Oncol. 2019 Mar;10(2):210-215. doi: 10.1016/j.jgo.2018.11.004. Epub 2018 Nov 28. PMID 30503312
- RESULTOrtland I, Mendel Ott M, Kowar M, Sippel C, Jaehde U, Jacobs AH, Ko YD. Comparing the performance of the CARG and the CRASH score for predicting toxicity in older patients with cancer. J Geriatr Oncol. 2020 Jul;11(6):997-1005. doi: 10.1016/j.jgo.2019.12.016. Epub 2020 Jan 9. PMID 31928942
- RESULTNishijima TF, Deal AM, Williams GR, Sanoff HK, Nyrop KA, Muss HB. Impact of the Cancer and Aging Research Group score and treatment intensity on survival and toxicity outcomes in older adults with advanced noncolorectal gastrointestinal cancers. Cancer. 2022 May 15;128(10):1929-1936. doi: 10.1002/cncr.34135. Epub 2022 Feb 11. PMID 35147991
- RESULTDuMontier C, Sedrak MS, Soo WK, Kenis C, Williams GR, Haase K, Harneshaug M, Mian H, Loh KP, Rostoft S, Dale W, Cohen HJ. Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper. J Geriatr Oncol. 2020 Mar;11(2):203-211. doi: 10.1016/j.jgo.2019.08.005. Epub 2019 Aug 23. PMID 31451439