Clinical trial · Interventional
A Transoral Retropterygoid Approach to Resect Recurrent Nasopharyngeal Carcinoma
Endoscopic Transoral Retropterygoid Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: a Prospective, Single-arm, Exploratory Trial
NCT05432219CI-TRIAL-00059306unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a a prospective, single-arm, and exploratory study of endoscopic resection of recurrent nasopharyngeal carcinoma via transoral retropterygoid approach.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Nasopharyngeal Carcinoma | Nasopharyngeal Carcinoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| endoscopic surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Endoscopic Transoral Retropterygoid Nasopharyngectomy
- description
- a novel endoscopic approach to resect nasopharyngeal carcinoma
- interventionNames
- Procedure: endoscopic surgery
Primary outcomes (1)
- measure
- Margin-negative (R0) resection rate
- timeFrame
- once the pathology results come out, up to 14 days
- description
- The rate of the margin-negative resection of the nasopharyngeal carcinoma
Secondary outcomes (9)
- measure
- Rate of a complete resection based on imaging findings
- timeFrame
- within 7 days after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pathology or radiography confirmed recurrent nasopharyngeal carcinoma. * AJCC rT2-T4 which can be surgically removed. * No distant metastasis. * aged 18 or more than 18 years old. * With or without lymph node metastasis, which can be surgically removed. * No severe restricted mouth opening, and oral approach eligible. * Sufficient organ function. * With signed informed consent. * ECOG score 0-2, and general physical condition can tolerate general anesthesia surgery. Exclusion Criteria: * Primary nasopharyngeal carcinoma * The patient has surgical contraindications: such as severe cardiopulmonary disease and coagulation dysfunction, etc. * The patient has any situation that may hinder study compliance or the safety during the study period. * Suffer from uncontrolled disease which could interfere with treatment. * Uncontrolled active infection. * Pregnant or breastfeeding women * There are some other situations that are not suitable for entry into the study.
References
Publications (0)
Data not yet available
No reference posted for this study.