Clinical trial · Interventional
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety
NCT05427058CI-TRIAL-00091973recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compared the efficacy and safety of superior hypogastric plexus block and ganglion impar block procedures on the management of pelvic and perineal cancer pain in patients with cervical and endometrial cancer
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ganglion Impar Block | Procedure | — | UNRESOLVED |
| Superior Hypogastric Plexus Block | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- group 1: superior hypogastric plexus block group
- description
- Device: C-arm fluoroscopic device Drug: lidocaine + alcohol
- interventionNames
- Procedure: Superior Hypogastric Plexus Block
- type
- EXPERIMENTAL
- label
- group 2: ganglion impar block group
- description
- Device: C-arm fluoroscopic device Drug: lidocaine + alcohol
- interventionNames
- Procedure: Ganglion Impar Block
Primary outcomes (3)
- measure
- Numerical rating scale (NRS)
- timeFrame
- 3 month
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Unbearable cancer pain that is resistant to WHO (World Health Organization) pain ladder at least 2 weeks medication * The patient is tired of taking medication orally or complications of current medication (respiratory depression, nausea, vomiting, opioid-induced constipation, gastrointestinal disturbances) * Patients with pelvic floor pain diagnosed by a (Fellow of Interventional Pain Practice) FIPP-certified pain specialist * Patients with pain in the perineum diagnosed by a FIPP-certified pain specialist * Numerical Rating Scale \>4 * \>18 years old * Able and willing to sign an informed consent Exclusion Criteria: * Refuse to be included in the research * Blood clotting disorders (including taking anticoagulant drugs) * Local infection in the area of action * Loss to follow up Drop-out Criteria: * Loss to follow up * Intervention complications occur * Failed intervention
References
Publications (42)
- BACKGROUNDFowler JR, Maani EV, Dunton CJ, Gasalberti DP, Jack BW. Cervical Cancer. 2023 Nov 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK431093/ PMID 28613745
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- BACKGROUNDYoon SY, Oh J. Neuropathic cancer pain: prevalence, pathophysiology, and management. Korean J Intern Med. 2018 Nov;33(6):1058-1069. doi: 10.3904/kjim.2018.162. Epub 2018 Jun 25. PMID 29929349
- BACKGROUNDSchmidt BL, Hamamoto DT, Simone DA, Wilcox GL. Mechanism of cancer pain. Mol Interv. 2010 Jun;10(3):164-78. doi: 10.1124/mi.10.3.7. PMID 20539035
- BACKGROUNDBhatnagar S, Gupta M. Evidence-based Clinical Practice Guidelines for Interventional Pain Management in Cancer Pain. Indian J Palliat Care. 2015 May-Aug;21(2):137-47. doi: 10.4103/0973-1075.156466. PMID 26009665
- BACKGROUNDGunduz OH, Kenis-Coskun O. Ganglion blocks as a treatment of pain: current perspectives. J Pain Res. 2017 Dec 14;10:2815-2826. doi: 10.2147/JPR.S134775. eCollection 2017. PMID 29276402
- BACKGROUNDKhan MA, Ashrafi SH, Decker SJ. The hepatic ultrastructure of chlordene-fed pigeons. Arch Environ Contam Toxicol. 1977;5(4):385-402. doi: 10.1007/BF02220919. PMID 196561
- BACKGROUNDRaja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ, Mogil JS, Ringkamp M, Sluka KA, Song XJ, Stevens B, Sullivan MD, Tutelman PR, Ushida T, Vader K. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020 Sep 1;161(9):1976-1982. doi: 10.1097/j.pain.0000000000001939.